STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
EJG07995.1Peptidase S16, Lon-like protease; PFAM: Magnesium chelatase, subunit ChlI; Sigma-54 interaction domain; Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: lon-related putative ATP-dependent protease; COGs: COG1067 ATP-dependent protease; InterPro IPR003593:IPR004663:IPR000523:IPR008269; KEGG: mem:Memar_0276 ATP-dependent protease Lon; PFAM: Peptidase S16, lon C-terminal; Magnesium chelatase, ChlI subunit; SMART: ATPase, AAA+ type, core; SPTR: Lon-B peptidase, Serine peptidase, MEROPS family S16; TIGRFAM: Peptidase S16, archaeal lon homologs; Belongs to the peptidase S16 family. (642 aa)    
Predicted Functional Partners:
EJG07996.1
PFAM: Putative modulator of DNA gyrase; COGs: COG0312 Zn-dependent protease and their inactivated homologs; InterPro IPR002510; KEGG: mem:Memar_0277 peptidase U62, modulator of DNA gyrase; PFAM: Peptidase U62, modulator of DNA gyrase; SPTR: Peptidase U62, modulator of DNA gyrase; overlaps another CDS with the same product name.
     
 0.944
EJG07997.1
PFAM: Putative modulator of DNA gyrase; COGs: COG0312 Zn-dependent protease and their inactivated homologs; InterPro IPR002510; KEGG: mbn:Mboo_2389 peptidase U62, modulator of DNA gyrase; PFAM: Peptidase U62, modulator of DNA gyrase; SPTR: Peptidase U62, modulator of DNA gyrase; overlaps another CDS with the same product name.
       0.939
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
  
 0.937
dnaK
Chaperone protein dnaK; Acts as a chaperone.
 
  
 0.907
EJG07989.1
PFAM: TCP-1/cpn60 chaperonin family; TIGRFAM: thermosome, various subunits, archaeal; COGs: COG0459 Chaperonin GroEL (HSP60 family); InterPro IPR002423; KEGG: mpl:Mpal_2699 chaperonin Cpn60/TCP-1; PFAM: Chaperonin Cpn60/TCP-1; SPTR: Chaperonin Cpn60/TCP-1.
  
  
 0.852
EJG08286.1
Thermosome; PFAM: TCP-1/cpn60 chaperonin family; TIGRFAM: thermosome, various subunits, archaeal; T-complex protein 1, eta subunit; COGs: COG0459 Chaperonin GroEL (HSP60 family); InterPro IPR002423:IPR012714; KEGG: mem:Memar_2346 thermosome; PFAM: Chaperonin Cpn60/TCP-1; SPTR: Thermosome subunit; TIGRFAM: Thermosome, archaeal.
  
  
 0.852
EJG07998.1
PFAM: SigmaK-factor processing regulatory protein BofA; TIGRFAM: pro-sigmaK processing inhibitor BofA; InterPro IPR010001; KEGG: mem:Memar_0279 hypothetical protein; PFAM: SigmaK-factor processing regulatory BofA; SPTR: Putative uncharacterized protein.
       0.835
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
  
 0.751
EJG05993.1
Hypothetical protein; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; KEGG: mpl:Mpal_0311 hypothetical protein; SPTR: Putative uncharacterized protein.
 
   
 0.732
EJG07992.1
Nucleotide binding protein, PINc; COGs: COG1439 nucleic acid-binding protein consists of a PIN domain and a Zn-ribbon module; KEGG: mbn:Mboo_2393 nucleotide binding protein, PINc; SPTR: Nucleotide binding protein, PINc.
 
     0.731
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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