Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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EJG08056.1Histidine triad (HIT) protein; PFAM: HIT domain; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310; KEGG: pmx:PERMA_0670 protein hit; PFAM: Histidine triad (HIT) protein; SPTR: Protein hit. (122 aa)    
Predicted Functional Partners:
EJG07799.1
PFAM: Phosphoribulokinase / Uridine kinase family; COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: mem:Memar_1934 phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; SPTR: Phosphoribulokinase/uridine kinase.
   
 0.791
EJG08116.1
PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I; COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: mem:Memar_0335 glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic region; Glutamine synthetase, beta-Grasp; SPTR: L-glutamine synthetase; TIGRFAM: Glutamine synthetase type I.
  
 
 0.704
lysS
PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; COGs: COG1190 Lysyl-tRNA synthetase (class II); HAMAP: Lysyl-tRNA synthetase; InterPro IPR002313:IPR004365:IPR004364; KEGG: mem:Memar_2341 lysyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Lysyl-tRNA synthetase; TIGRFAM: Lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
 0.630
EJG08345.1
PFAM: Histone deacetylase domain; COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: mem:Memar_2236 histone deacetylase superfamily protein; PFAM: Histone deacetylase superfamily; SPTR: Histone deacetylase superfamily.
   
 0.620
EJG06316.1
PFAM: NUDIX domain; InterPro IPR000086; KEGG: mpi:Mpet_0609 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; SPTR: NUDIX hydrolase.
  
 0.572
EJG07778.1
PFAM: Oxidoreductase molybdopterin binding domain; InterPro IPR000572; KEGG: mla:Mlab_1026 hypothetical protein; PFAM: Oxidoreductase, molybdopterin binding; SPTR: Putative uncharacterized protein.
   
  0.491
EJG08055.1
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterProIPR001789:IPR000014:IPR003594:IPR013655:IPR 013767:IPR013656; KEGG: mbn:Mboo_2110 multi-sensor signal transduction histidine kinase; PFAM: Signal transduction response regulator, receiver region; PAS fold-3; PAS fold; PAS fold-4; ATP-binding region, ATPase-like; SMART: Signal transduction res [...]
  
    0.471
tbp
TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
    
 0.424
EJG07268.1
PFAM: Transcription factor TFIID (or TATA-binding protein, TBP); COGs: COG2101 TATA-box binding protein (TBP) component of TFIID and TFIIIB; InterPro IPR000814; KEGG: tba:TERMP_01858 TatA-box binding protein; PFAM: TATA-box binding; SPTR: Transcription factor TFIID (Or TATA-binding protein, TBP).
    
 0.424
tbp-2
TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
    
 0.424
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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