Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
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EJG08100.1Anti-sigma-factor antagonist; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR002645:IPR003658; KEGG: mem:Memar_2467 anti-sigma-factor antagonist; PFAM: Sulphate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist; TIGRFAM: Anti-sigma factor antagonist. (118 aa)    
Predicted Functional Partners:
EJG07354.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase); InterPro IPR003594; KEGG: pth:PTH_2273 anti-sigma regulatory factor; PFAM: ATP-binding region, ATPase-like; SPTR: Anti-sigma regulatory factor.
 
 0.974
EJG07355.1
Protein serine/threonine phosphatase; PFAM: 5TMR of 5TMR-LYT; Stage II sporulation protein E (SpoIIE); COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932:IPR011620:IPR010822; KEGG: mem:Memar_2468 stage II sporulation E family protein; PFAM: Sporulation stage II, protein E C-terminal; Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region; SMART: Protein phosphatase 2C-related; SPTR: Stage II sporulation E family protein.
 
 0.933
EJG06183.1
PFAM: Cache domain; HAMP domain; Stage II sporulation protein E (SpoIIE); COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR003660:IPR001932:IPR004010:IPR010822; KEGG: mbn:Mboo_0643 stage II sporulation E family protein; PFAM: Sporulation stage II, protein E C-terminal; HAMP linker domain; Cache; SMART: Protein phosphatase 2C-related; HAMP linker domain; SPTR: Stage II sporulation E family protein.
 
 0.930
EJG08186.1
Hypothetical protein; TIGRFAM: Chlamydial polymorphic outer membrane protein repeat; KEGG: mla:Mlab_1452 hypothetical protein; SPTR: Putative anti-sigma regulatory factor, serine/threonine protein kinase.
  
 0.901
EJG06134.1
Putative signal transduction histidine kinase; PFAM: Natural resistance-associated macrophage protein; 5TMR of 5TMR-LYT; COGs: COG3275 Putative regulator of cell autolysis; InterPro IPR011620; KEGG: mpi:Mpet_2152 signal transduction histidine kinase LytS; PFAM: Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region; SPTR: Signal transduction histidine kinase, LytS.
  
 0.778
cofG
FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
    0.698
EJG08101.1
AAA ATPase; COGs: COG1341 GTPase or GTP-binding protein; KEGG: mem:Memar_1427 AAA ATPase; SPTR: AAA ATPase.
       0.661
cofH
FO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
  
    0.603
EJG06093.1
PFAM: Radical SAM superfamily; TIGRFAM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; radical SAM domain protein, CofH subfamily; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197:IPR019940:IPR020050; KEGG: mem:Memar_0047 radical SAM domain-containing protein; PFAM: Radical SAM; SPTR: FO synthase subunit 2; TIGRFAM: Complex F420, CofH; FO synthase, subunit 2.
  
    0.603
EJG08102.1
PFAM: CBS domain; COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644; KEGG: mem:Memar_0345 signal-transduction protein; PFAM: Cystathionine beta-synthase, core; SMART: Cystathionine beta-synthase, core; SPTR: Putative signal-transduction protein with CBS domains.
 
    0.553
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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