STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG08255.1PFAM: 2Fe-2S iron-sulfur cluster binding domain; Cysteine-rich domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; COGs: COG0247 Fe-S oxidoreductase; InterPro IPR001041:IPR004017:IPR004489; KEGG: mem:Memar_0220 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: Cysteine-rich region, CCG; Ferredoxin; SPTR: Thiol-driven fumarate reductase, iron-sulfur protein; TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein. (487 aa)    
Predicted Functional Partners:
EJG08254.1
PFAM: domain; FAD binding domain; COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR003953; KEGG: mpl:Mpal_0402 succinate dehydrogenase flavoprotein subunit; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; SPTR: Succinate dehydrogenase.
 
 
 0.999
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
  
 0.997
EJG07048.1
PFAM: Fumarate hydratase (Fumerase); TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; COGs: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I N-terminal domain; InterPro IPR004646; KEGG: mem:Memar_0847 tartrate/fumarate subfamily Fe-S type hydro-lyase alpha subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region; SPTR: Fumarase alpha subunit; TIGRFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region.
    
 0.996
EJG07049.1
PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; COGs: COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I C-terminal domain; InterPro IPR004647; KEGG: mem:Memar_0846 tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate beta region; SPTR: Fumarase beta subunit; TIGRFAM: Fe-S type hydro-lyases tartrate/fumarate beta region.
    
 0.992
EJG07054.1
PFAM: CoA-ligase; ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650:IPR005811:IPR005809; KEGG: mbn:Mboo_0727 succinyl-CoA synthetase, beta subunit; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; ATP-citrate lyase/succinyl-CoA ligase; SPTR: Succinyl-CoA synthetase, beta subunit; TIGRFAM: Succinyl-CoA synthetase, beta subunit.
 
 
 0.991
EJG06477.1
PFAM: Cysteine-rich domain; TIGRFAM: CoB--CoM heterodisulfide reductase, subunit B; COGs: COG2048 Heterodisulfide reductase subunit B; InterPro IPR017678:IPR004017; KEGG: mhu:Mhun_1837 protein of unknown function DUF224, cysteine-rich region; PFAM: Cysteine-rich region, CCG; SPTR: CoB--CoM heterodisulfide reductase subunit B; TIGRFAM: CoB--CoM heterodisulphide reductase, subunit B.
 
 0.963
EJG06478.1
TIGRFAM: CoB--CoM heterodisulfide reductase, subunit C; COGs: COG1150 Heterodisulfide reductase subunit C; InterPro IPR017680; KEGG: mhu:Mhun_1836 4Fe-4S ferredoxin, iron-sulfur binding; SPTR: CoB--CoM heterodisulfide reductase subunit C; TIGRFAM: CoB--CoM heterodisulphide reductase, subunit C.
 
 0.961
EJG06475.1
PFAM: Methyl-viologen-reducing hydrogenase, delta subunit; COGs: COG1908 Coenzyme F420-reducing hydrogenase delta subunit; InterPro IPR003813; KEGG: mpi:Mpet_2476 methyl-viologen-reducing hydrogenase subunit delta; PFAM: Methyl-viologen-reducing hydrogenase, delta subunit; SPTR: Methyl-viologen-reducing hydrogenase delta subunit.
 
  
 0.954
EJG08252.1
Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728:IPR010918:IPR004733; KEGG: mem:Memar_0223 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein, C-terminal; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase.
     
 0.932
EJG08253.1
PFAM: Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR001048:IPR002912:IPR005260:IPR001341; KEGG: mpl:Mpal_0401 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; Belongs to the aspartokinase family.
       0.928
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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