STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
EJG08357.1PFAM: Ham1 family; TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; COGs: COG0127 Xanthosine triphosphate pyrophosphatase; InterPro IPR002637; KEGG: mpl:Mpal_0597 non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; PFAM: Ham1-like protein; SPTR: Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; TIGRFAM: Ham1-like protein; Belongs to the HAM1 NTPase family. (165 aa)    
Predicted Functional Partners:
EJG07827.1
GMP synthase, large subunit; PFAM: GMP synthase C terminal domain; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterPro IPR001674:IPR018318; KEGG: mem:Memar_1900 GMP synthase subunit B; PFAM: GMP synthase, C-terminal; tRNA methyl transferase-like; SPTR: GMP synthase [glutamine-hydrolyzing] subunit B; TIGRFAM: GMP synthase, C-terminal.
 
 
 0.991
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 0.989
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.988
guaAA
GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP.
 
 
 0.986
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.980
EJG08206.1
5'-Nucleotidase domain-containing protein; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: mem:Memar_1147 5'-nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SPTR: 5'-Nucleotidase domain protein.
  
 
 0.950
EJG08356.1
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.
     
 0.944
rps24e
PFAM: Ribosomal protein S24e; COGs: COG2004 Ribosomal protein S24E; HAMAP: 30S ribosomal protein S24e; InterPro IPR001976; KEGG: mem:Memar_2245 ribosomal protein S24e; PFAM: Ribosomal protein S24e; SPTR: SSU ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family.
  
    0.909
rps27ae
PFAM: Ribosomal protein S27a; COGs: COG1998 Ribosomal protein S27AE; HAMAP: 30S ribosomal protein S27ae; InterPro IPR002906; KEGG: mhu:Mhun_2867 ribosomal protein S27a; PFAM: Ribosomal protein S27a; SPTR: 30S ribosomal protein S27ae; Belongs to the eukaryotic ribosomal protein eS31 family.
       0.908
rpl40e
PFAM: Ribosomal L40e family; HAMAP: 50S ribosomal protein L40e; InterPro IPR001975; KEGG: mbn:Mboo_0238 50S ribosomal protein L40e; PFAM: Ribosomal protein L40e; SPTR: 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
       0.859
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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