STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpXProtease htpX; PFAM: Peptidase family M48; COGs: COG0501 Zn-dependent protease with chaperone function; HAMAP: protease htpX; InterPro IPR001915; KEGG: mpl:Mpal_0594 heat shock protein HtpX; PFAM: Peptidase M48, Ste24p; SPTR: Protease HtpX homolog; Belongs to the peptidase M48B family. (295 aa)    
Predicted Functional Partners:
EJG06917.1
Thiamine pyrophosphate TPP-binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766; KEGG: mem:Memar_1930 thiamine pyrophosphate binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, N-terminal TPP binding region; SPTR: Py [...]
  
 
 0.980
EJG06016.1
Auxin Efflux Carrier; PFAM: Membrane transport protein; COGs: COG0679 permease; InterPro IPR004776; KEGG: mem:Memar_0121 auxin efflux carrier; PFAM: Auxin efflux carrier; SPTR: Auxin Efflux Carrier.
  
  
 0.937
rpl4
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
  
 0.912
EJG08255.1
PFAM: 2Fe-2S iron-sulfur cluster binding domain; Cysteine-rich domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; COGs: COG0247 Fe-S oxidoreductase; InterPro IPR001041:IPR004017:IPR004489; KEGG: mem:Memar_0220 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: Cysteine-rich region, CCG; Ferredoxin; SPTR: Thiol-driven fumarate reductase, iron-sulfur protein; TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein.
 
  
 0.876
EJG08175.1
PFAM: ACT domain; COGs: COG1707 ACT domain-containing protein; InterPro IPR002912; KEGG: mem:Memar_0435 amino acid-binding ACT domain-containing protein; PFAM: Amino acid-binding ACT; SPTR: Amino acid-binding ACT domain protein.
  
    0.872
EJG07054.1
PFAM: CoA-ligase; ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650:IPR005811:IPR005809; KEGG: mbn:Mboo_0727 succinyl-CoA synthetase, beta subunit; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; ATP-citrate lyase/succinyl-CoA ligase; SPTR: Succinyl-CoA synthetase, beta subunit; TIGRFAM: Succinyl-CoA synthetase, beta subunit.
  
 
 0.868
EJG07597.1
PFAM: GHMP kinases N terminal domain; COGs: COG1829 kinase (sugar kinase superfamily); InterPro IPR006204; KEGG: mem:Memar_1235 GHMP kinase; PFAM: GHMP kinase; SPTR: Pantothenate kinase.
  
    0.868
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.864
EJG07048.1
PFAM: Fumarate hydratase (Fumerase); TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; COGs: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I N-terminal domain; InterPro IPR004646; KEGG: mem:Memar_0847 tartrate/fumarate subfamily Fe-S type hydro-lyase alpha subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region; SPTR: Fumarase alpha subunit; TIGRFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region.
  
 
 0.841
EJG07049.1
PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; COGs: COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I C-terminal domain; InterPro IPR004647; KEGG: mem:Memar_0846 tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate beta region; SPTR: Fumarase beta subunit; TIGRFAM: Fe-S type hydro-lyases tartrate/fumarate beta region.
  
 
 0.841
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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