STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
thiSThiamin biosynthesis protein; Pfam match to PF02597.18 ThiS. (63 aa)    
Predicted Functional Partners:
thiG
ThiGH complex, thiazole synthase subunit ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.991
thiF
ThiS adenylyltransferase; Pfam matches to PF00899.19 ThiF, and to PF14453.4 ThiS-like.
 
  0.984
thiC
HMP-P synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.852
ARE80382.1
Thiamine monophosphate synthase/TENI family protein; Pfam match to PF02581.15 TMP-TENI.
 
  
 0.812
thiD
Hydroxymethylpyrimidine kinase / phosphohydroxymethylpyrimidine kinase; Bifunctional; Pfam match to PF08543.10 Phos_pyr_kin.
  
    0.811
thiH
ThiGH complex, tyrosine lyase subunit ThiH; Pfam matches to PF06968.11 BATS, and to PF04055.19 Radical_SAM.
 
    0.792
thiE
Thiamine phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.768
ARE79755.1
Adenine nucleotide alpha hydrolase, possible tRNA 2-thiocytidine biosynthesis protein; Pfam match to PF01171.18 ATP_bind_3; Belongs to the TtcA family.
  
   0.619
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
  
   0.617
ARE81221.1
N-acetyl sugar amidotransferase.
  
   0.617
Your Current Organism:
Campylobacter helveticus
NCBI taxonomy Id: 28898
Other names: ATCC 51209, C. helveticus, CCUG 30682, CIP 104877, LMG 12638, LMG 19528, LMG:12638, LMG:19528, NCTC 12470
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