STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACI21216.1Conserved hypothetical protein; Identified by match to protein family HMM PF07949. (217 aa)    
Predicted Functional Partners:
dacA
Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
  
 0.998
glmM
Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
  
  
 0.798
ACI21916.1
Conserved hypothetical protein.
       0.773
ACI21064.1
Putative regulatory protein, FmdB family; Identified by match to protein family HMM TIGR02605.
       0.540
ACI21124.1
Acetoacetate metabolism regulatory protein AtoC; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728.
       0.418
ACI22141.1
acetyl-CoA synthetase; Identified by match to protein family HMM PF00583; match to protein family HMM PF02629.
       0.418
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.418
ACI21717.1
Transglycosylase, Slt family; Identified by match to protein family HMM PF01464; match to protein family HMM PF01476.
 
    0.410
Your Current Organism:
Thermodesulfovibrio yellowstonii
NCBI taxonomy Id: 289376
Other names: T. yellowstonii DSM 11347, Thermodesulfovibrio yellowstonii DSM 11347
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