grpE protein (Thermodesulfobacterium commune)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Thermodesulfobacterium commune

NCBI taxonomy Id: 289377
Other names: T. commune DSM 2178, Thermodesulfobacterium commune DSM 2178

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIH03763.1	AIH04250.1	HL41_02550	HL41_05510	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
AIH03763.1	clpB	HL41_02550	HL41_03560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.631
AIH03763.1	dnaK	HL41_02550	HL41_01160	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.975
AIH03763.1	groEL	HL41_02550	HL41_04625	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.701
AIH03763.1	groS	HL41_02550	HL41_04630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.513
AIH03763.1	grpE	HL41_02550	HL41_01155	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.909
AIH03763.1	hslU	HL41_02550	HL41_09065	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.603
AIH03763.1	hslV	HL41_02550	HL41_09070	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptidase; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.459
AIH04250.1	AIH03763.1	HL41_05510	HL41_02550	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
AIH04250.1	clpB	HL41_05510	HL41_03560	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.578
AIH04250.1	dnaK	HL41_05510	HL41_01160	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.990
AIH04250.1	groEL	HL41_05510	HL41_04625	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.748
AIH04250.1	groS	HL41_05510	HL41_04630	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.571
AIH04250.1	grpE	HL41_05510	HL41_01155	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.896
AIH04250.1	hslU	HL41_05510	HL41_09065	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.603
AIH04250.1	hslV	HL41_05510	HL41_09070	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptidase; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.459
AIH04259.1	clpB	HL41_05580	HL41_03560	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.578
AIH04259.1	dnaK	HL41_05580	HL41_01160	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.911
AIH04259.1	groEL	HL41_05580	HL41_04625	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.701
AIH04259.1	groS	HL41_05580	HL41_04630	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.513