dnaK protein (Thermodesulfobacterium commune)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Thermodesulfobacterium commune

NCBI taxonomy Id: 289377
Other names: T. commune DSM 2178, Thermodesulfobacterium commune DSM 2178

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIH03763.1	AIH04250.1	HL41_02550	HL41_05510	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
AIH03763.1	clpB	HL41_02550	HL41_03560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.631
AIH03763.1	dnaK	HL41_02550	HL41_01160	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.975
AIH03763.1	groEL	HL41_02550	HL41_04625	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.701
AIH03763.1	groS	HL41_02550	HL41_04630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.513
AIH03763.1	grpE	HL41_02550	HL41_01155	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.909
AIH03953.1	AIH04705.1	HL41_03700	HL41_08630	Cytochrome C3 subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.743
AIH03953.1	clpB	HL41_03700	HL41_03560	Cytochrome C3 subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.461
AIH03953.1	dnaK	HL41_03700	HL41_01160	Cytochrome C3 subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.870
AIH03953.1	groEL	HL41_03700	HL41_04625	Cytochrome C3 subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.570
AIH03953.1	grpE	HL41_03700	HL41_01155	Cytochrome C3 subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.666
AIH04250.1	AIH03763.1	HL41_05510	HL41_02550	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
AIH04250.1	clpB	HL41_05510	HL41_03560	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.578
AIH04250.1	dnaK	HL41_05510	HL41_01160	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.990
AIH04250.1	groEL	HL41_05510	HL41_04625	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.748
AIH04250.1	groS	HL41_05510	HL41_04630	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.571
AIH04250.1	grpE	HL41_05510	HL41_01155	Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.896
AIH04259.1	clpB	HL41_05580	HL41_03560	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.578
AIH04259.1	dnaK	HL41_05580	HL41_01160	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.911
AIH04259.1	groEL	HL41_05580	HL41_04625	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.701