KSV57797.1 protein (Acetivibrio ethanolgignens)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KSV57797.1

ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)

Predicted Functional Partners:

KSV57796.1

0.964

KSV57798.1

0.957

KSV57423.1

0.820

KSV60261.1

0.782

KSV58535.1

0.732

KSV60601.1

0.609

KSV58431.1

0.609

KSV60324.1

0.589

KSV57421.1

0.558

KSV60549.1

0.543

Your Current Organism:

Acetivibrio ethanolgignens

NCBI taxonomy Id: 290052
Other names: A. ethanolgignens, ATCC 33324, Acetivibrio ethanoligignens, DSM 3005, LMG 7055, LMG:7055, strain 77-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KSV57421.1	KSV57423.1	ASU35_16285	ASU35_16300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.692
KSV57421.1	KSV57797.1	ASU35_16285	ASU35_14965	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.558
KSV57421.1	KSV57798.1	ASU35_16285	ASU35_14970	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.541
KSV57421.1	KSV58535.1	ASU35_16285	ASU35_12525	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.541
KSV57421.1	KSV60261.1	ASU35_16285	ASU35_05755	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.541
KSV57423.1	KSV57421.1	ASU35_16300	ASU35_16285	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.692
KSV57423.1	KSV57796.1	ASU35_16300	ASU35_14960	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.475
KSV57423.1	KSV57797.1	ASU35_16300	ASU35_14965	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
KSV57423.1	KSV58431.1	ASU35_16300	ASU35_13005	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.619
KSV57423.1	KSV60549.1	ASU35_16300	ASU35_05070	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
KSV57423.1	KSV60601.1	ASU35_16300	ASU35_00030	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.609
KSV57796.1	KSV57423.1	ASU35_14960	ASU35_16300	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.475
KSV57796.1	KSV57797.1	ASU35_14960	ASU35_14965	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
KSV57796.1	KSV57798.1	ASU35_14960	ASU35_14970	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
KSV57796.1	KSV58535.1	ASU35_14960	ASU35_12525	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.475
KSV57796.1	KSV60324.1	ASU35_14960	ASU35_06120	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flagellar basal body and hook protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.589
KSV57797.1	KSV57421.1	ASU35_14965	ASU35_16285	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.558
KSV57797.1	KSV57423.1	ASU35_14965	ASU35_16300	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
KSV57797.1	KSV57796.1	ASU35_14965	ASU35_14960	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
KSV57797.1	KSV57798.1	ASU35_14965	ASU35_14970	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.957

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.841

expected number of edges:

35

PPI enrichment p-value:

0.988

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019842

Vitamin binding

5 of 54

1.57

1.64

0.00011

GO:0030976

Thiamine pyrophosphate binding

3 of 9

2.13

1.58

0.00090

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 24

1.7

1.13

0.0047

GO:0005506

Iron ion binding

3 of 52

1.36

0.76

0.0202

GO:0036094

Small molecule binding

8 of 644

0.7

0.52

0.0043

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1749

Pyruvate:ferredoxin oxidoreductase core domain II

3 of 5

2.38

1.72

0.00061

CL:1313

Histidine biosynthesis

2 of 5

2.2

0.89

0.0222

CL:4893

Mixed, incl. Peptidase M3A/M3B, and acyl-CoA hydrolase activity

2 of 6

2.13

0.86

0.0247

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

4 of 41

1.59

1.49

0.00036

map00020

Citrate cycle (TCA cycle)

3 of 23

1.72

1.31

0.0018

map00010

Glycolysis / Gluconeogenesis

3 of 39

1.49

1.04

0.0048

map00620

Pyruvate metabolism

3 of 55

1.34

0.89

0.0080

map00450

Selenocompound metabolism

2 of 29

1.44

0.65

0.0437

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

3 of 11

2.04

1.7

0.00045

KW-0670

Pyruvate

3 of 18

1.82

1.44

0.0011

KW-0479

Metal-binding

7 of 278

1.0

0.93

0.00025

KW-0368

Histidine biosynthesis

2 of 12

1.82

0.81

0.0273

KW-0028

Amino-acid biosynthesis

3 of 68

1.25

0.68

0.0273

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

3 of 5

2.38

1.8

0.00042

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

3 of 6

2.3

1.79

0.00042

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

3 of 6

2.3

1.79

0.00042

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

3 of 8

2.18

1.76

0.00042

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037112

Pyruvate-flavodoxin oxidoreductase, EKR domain superfamily

3 of 3

2.6

1.85

0.00039

IPR019456

Pyruvate-flavodoxin oxidoreductase, EKR domain

3 of 3

2.6

1.85

0.00039

IPR011895

Pyruvate-flavodoxin oxidoreductase

3 of 3

2.6

1.85

0.00039

IPR033412

Pyruvate:ferredoxin oxidoreductase, core domain II

3 of 5

2.38

1.82

0.00039

IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain

3 of 6

2.3

1.8

0.00039

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00890

Domain of unknown function

3 of 3

2.6

2.4

3.42e-05

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