STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PENO1_032390Poly [ADP-ribose] polymerase. (663 aa)    
Predicted Functional Partners:
PENO1_047260
ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.
   
 
 0.895
PENO1_007370
Uncharacterized protein.
    
 0.894
PENO1_008850
DNA helicase, ATP-dependent, Ku type.
   
 
 0.865
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.855
PENO1_099040
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 
 0.848
PENO1_094520
Winged helix-turn-helix transcription repressor DNA-binding.
    
 0.796
PENO1_062430
Rad4 beta-hairpin domain 1.
    
  0.795
PENO1_022570
Rad4 beta-hairpin domain 1.
    
  0.795
PENO1_033480
DNA polymerase family X.
    
 0.793
PENO1_100270
Ubiquitin-conjugating enzyme, E2; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.768
Your Current Organism:
Penicillium sp. occitanis
NCBI taxonomy Id: 290292
Other names: P. sp. 'occitanis', Penicillium occitanis, Penicillium sp. 'occitanis'
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