node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | PENO1_007370 | A0A2H3IEX3 | A0A2H3IR93 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.675 |
FEN1 | PENO1_008850 | A0A2H3IEX3 | A0A2H3J371 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA helicase, ATP-dependent, Ku type. | 0.741 |
FEN1 | PENO1_022570 | A0A2H3IEX3 | A0A2H3IW13 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Rad4 beta-hairpin domain 1. | 0.596 |
FEN1 | PENO1_032390 | A0A2H3IEX3 | A0A2H3J1J6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Poly [ADP-ribose] polymerase. | 0.855 |
FEN1 | PENO1_033480 | A0A2H3IEX3 | A0A2H3ISS6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase family X. | 0.847 |
FEN1 | PENO1_047260 | A0A2H3IEX3 | A0A2H3IXC0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. | 0.663 |
FEN1 | PENO1_062430 | A0A2H3IEX3 | A0A2H3I9K6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Rad4 beta-hairpin domain 1. | 0.596 |
FEN1 | PENO1_094520 | A0A2H3IEX3 | A0A2H3IAP8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Winged helix-turn-helix transcription repressor DNA-binding. | 0.866 |
PENO1_007370 | FEN1 | A0A2H3IR93 | A0A2H3IEX3 | Uncharacterized protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.675 |
PENO1_007370 | PENO1_008850 | A0A2H3IR93 | A0A2H3J371 | Uncharacterized protein. | DNA helicase, ATP-dependent, Ku type. | 0.408 |
PENO1_007370 | PENO1_032390 | A0A2H3IR93 | A0A2H3J1J6 | Uncharacterized protein. | Poly [ADP-ribose] polymerase. | 0.894 |
PENO1_007370 | PENO1_033480 | A0A2H3IR93 | A0A2H3ISS6 | Uncharacterized protein. | DNA polymerase family X. | 0.513 |
PENO1_008850 | FEN1 | A0A2H3J371 | A0A2H3IEX3 | DNA helicase, ATP-dependent, Ku type. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.741 |
PENO1_008850 | PENO1_007370 | A0A2H3J371 | A0A2H3IR93 | DNA helicase, ATP-dependent, Ku type. | Uncharacterized protein. | 0.408 |
PENO1_008850 | PENO1_022570 | A0A2H3J371 | A0A2H3IW13 | DNA helicase, ATP-dependent, Ku type. | Rad4 beta-hairpin domain 1. | 0.475 |
PENO1_008850 | PENO1_032390 | A0A2H3J371 | A0A2H3J1J6 | DNA helicase, ATP-dependent, Ku type. | Poly [ADP-ribose] polymerase. | 0.865 |
PENO1_008850 | PENO1_033480 | A0A2H3J371 | A0A2H3ISS6 | DNA helicase, ATP-dependent, Ku type. | DNA polymerase family X. | 0.844 |
PENO1_008850 | PENO1_047260 | A0A2H3J371 | A0A2H3IXC0 | DNA helicase, ATP-dependent, Ku type. | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. | 0.999 |
PENO1_008850 | PENO1_062430 | A0A2H3J371 | A0A2H3I9K6 | DNA helicase, ATP-dependent, Ku type. | Rad4 beta-hairpin domain 1. | 0.475 |
PENO1_008850 | PENO1_094520 | A0A2H3J371 | A0A2H3IAP8 | DNA helicase, ATP-dependent, Ku type. | Winged helix-turn-helix transcription repressor DNA-binding. | 0.744 |