node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
R1BI21_EMIHU | R1BUZ9_EMIHU | R1BI21 | R1BUZ9 | ATP-grasp domain-containing protein. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.672 |
R1BI21_EMIHU | R1BZS9_EMIHU | R1BI21 | R1BZS9 | ATP-grasp domain-containing protein. | Dimethylglycine dehydrogenase. | 0.598 |
R1BI21_EMIHU | R1C2C0_EMIHU | R1BI21 | R1C2C0 | ATP-grasp domain-containing protein. | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.588 |
R1BI21_EMIHU | R1CVB7_EMIHU | R1BI21 | R1CVB7 | ATP-grasp domain-containing protein. | Dimethylglycine dehydrogenase. | 0.598 |
R1BI21_EMIHU | R1DBM0_EMIHU | R1BI21 | R1DBM0 | ATP-grasp domain-containing protein. | Sarcosine dehydrogenase. | 0.598 |
R1BI21_EMIHU | R1DPK6_EMIHU | R1BI21 | R1DPK6 | ATP-grasp domain-containing protein. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.841 |
R1BI21_EMIHU | R1DY87_EMIHU | R1BI21 | R1DY87 | ATP-grasp domain-containing protein. | ATP-grasp domain-containing protein. | 0.984 |
R1BI21_EMIHU | R1EP98_EMIHU | R1BI21 | R1EP98 | ATP-grasp domain-containing protein. | ATP-grasp domain-containing protein. | 0.984 |
R1BI21_EMIHU | R1FKA8_EMIHU | R1BI21 | R1FKA8 | ATP-grasp domain-containing protein. | Sarcosine dehydrogenase. | 0.598 |
R1BI21_EMIHU | purD | R1BI21 | R1BKN5 | ATP-grasp domain-containing protein. | Phosphoribosylamine--glycine ligase. | 0.984 |
R1BUZ9_EMIHU | R1BI21_EMIHU | R1BUZ9 | R1BI21 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | ATP-grasp domain-containing protein. | 0.672 |
R1BUZ9_EMIHU | R1BZS9_EMIHU | R1BUZ9 | R1BZS9 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dimethylglycine dehydrogenase. | 0.543 |
R1BUZ9_EMIHU | R1C2C0_EMIHU | R1BUZ9 | R1C2C0 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.580 |
R1BUZ9_EMIHU | R1CVB7_EMIHU | R1BUZ9 | R1CVB7 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dimethylglycine dehydrogenase. | 0.543 |
R1BUZ9_EMIHU | R1DBM0_EMIHU | R1BUZ9 | R1DBM0 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Sarcosine dehydrogenase. | 0.543 |
R1BUZ9_EMIHU | R1DPK6_EMIHU | R1BUZ9 | R1DPK6 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.621 |
R1BUZ9_EMIHU | R1DY87_EMIHU | R1BUZ9 | R1DY87 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | ATP-grasp domain-containing protein. | 0.672 |
R1BUZ9_EMIHU | R1EP98_EMIHU | R1BUZ9 | R1EP98 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | ATP-grasp domain-containing protein. | 0.672 |
R1BUZ9_EMIHU | R1FKA8_EMIHU | R1BUZ9 | R1FKA8 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Sarcosine dehydrogenase. | 0.543 |
R1BUZ9_EMIHU | purD | R1BUZ9 | R1BKN5 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Phosphoribosylamine--glycine ligase. | 0.672 |