R1ELY1_EMIHU protein (Emiliania huxleyi) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

R1ELY1_EMIHU

Uncharacterized protein. (370 aa)

Predicted Functional Partners:

R1B7P1_EMIHU

0.979

R1CTF4_EMIHU

0.979

R1DEY8_EMIHU

0.979

R1F5C9_EMIHU

0.952

R1FCQ2_EMIHU

0.950

A0A0D3IHQ3

0.903

R1CI27_EMIHU

0.903

R1BNF1_EMIHU

0.900

R1BPC8_EMIHU

0.900

R1E105_EMIHU

0.900

Your Current Organism:

Emiliania huxleyi

NCBI taxonomy Id: 2903
Other names: E. huxleyi, Emiliania huxleyi (Lohmann) W.W.Hay & H.P.Mohler, Gephyrocapsa huxleyi, Pontosphaera huxleyi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0D3IHQ3	R1BNF1_EMIHU	A0A0D3IHQ3	R1BNF1	Abhydro_lipase domain-containing protein.	PNPLA domain-containing protein.	0.911
A0A0D3IHQ3	R1BPC8_EMIHU	A0A0D3IHQ3	R1BPC8	Abhydro_lipase domain-containing protein.	PNPLA domain-containing protein.	0.911
A0A0D3IHQ3	R1CI27_EMIHU	A0A0D3IHQ3	R1CI27	Abhydro_lipase domain-containing protein.	Abhydro_lipase domain-containing protein.	0.900
A0A0D3IHQ3	R1E105_EMIHU	A0A0D3IHQ3	R1E105	Abhydro_lipase domain-containing protein.	PNPLA domain-containing protein.	0.911
A0A0D3IHQ3	R1ELY1_EMIHU	A0A0D3IHQ3	R1ELY1	Abhydro_lipase domain-containing protein.	Uncharacterized protein.	0.903
A0A0D3IHQ3	R1F5C9_EMIHU	A0A0D3IHQ3	R1F5C9	Abhydro_lipase domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.901
R1B7P1_EMIHU	R1CTF4_EMIHU	R1B7P1	R1CTF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.900
R1B7P1_EMIHU	R1DEY8_EMIHU	R1B7P1	R1DEY8	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.900
R1B7P1_EMIHU	R1ELY1_EMIHU	R1B7P1	R1ELY1	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.979
R1B7P1_EMIHU	R1F5C9_EMIHU	R1B7P1	R1F5C9	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	FAD-binding PCMH-type domain-containing protein.	0.933
R1B7P1_EMIHU	R1FCQ2_EMIHU	R1B7P1	R1FCQ2	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	AAA_28 domain-containing protein.	0.946
R1BNF1_EMIHU	A0A0D3IHQ3	R1BNF1	A0A0D3IHQ3	PNPLA domain-containing protein.	Abhydro_lipase domain-containing protein.	0.911
R1BNF1_EMIHU	R1BPC8_EMIHU	R1BNF1	R1BPC8	PNPLA domain-containing protein.	PNPLA domain-containing protein.	0.951
R1BNF1_EMIHU	R1CI27_EMIHU	R1BNF1	R1CI27	PNPLA domain-containing protein.	Abhydro_lipase domain-containing protein.	0.911
R1BNF1_EMIHU	R1E105_EMIHU	R1BNF1	R1E105	PNPLA domain-containing protein.	PNPLA domain-containing protein.	0.901
R1BNF1_EMIHU	R1ELY1_EMIHU	R1BNF1	R1ELY1	PNPLA domain-containing protein.	Uncharacterized protein.	0.900
R1BNF1_EMIHU	R1F5C9_EMIHU	R1BNF1	R1F5C9	PNPLA domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.900
R1BPC8_EMIHU	A0A0D3IHQ3	R1BPC8	A0A0D3IHQ3	PNPLA domain-containing protein.	Abhydro_lipase domain-containing protein.	0.911
R1BPC8_EMIHU	R1BNF1_EMIHU	R1BPC8	R1BNF1	PNPLA domain-containing protein.	PNPLA domain-containing protein.	0.951
R1BPC8_EMIHU	R1CI27_EMIHU	R1BPC8	R1CI27	PNPLA domain-containing protein.	Abhydro_lipase domain-containing protein.	0.911

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Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.817

expected number of edges:

11

PPI enrichment p-value:

4.89e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019363

Pyridine nucleotide biosynthetic process

7 of 15

2.2

4.82

3.07e-11

GO:0019359

Nicotinamide nucleotide biosynthetic process

6 of 14

2.16

4.23

7.46e-10

GO:0009435

NAD biosynthetic process

5 of 12

2.15

3.54

3.73e-08

GO:0009165

Nucleotide biosynthetic process

8 of 77

1.55

2.73

1.11e-09

GO:0009117

Nucleotide metabolic process

9 of 111

1.44

2.49

3.08e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004514

Nicotinate-nucleotide diphosphorylase (carboxylating) activity

3 of 3

2.53

1.95

0.00024

GO:0004516

Nicotinate phosphoribosyltransferase activity

2 of 2

2.53

1.1

0.0099

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 40

1.41

0.69

0.0346

GO:0016740

Transferase activity

7 of 544

0.64

0.39

0.0346

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1020

0.48

0.32

0.0314

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1329

Mixed, incl. Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

10 of 29

2.07

6.28

3.84e-17

CL:1330

Mixed, incl. Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

9 of 22

2.14

6.17

1.14e-15

CL:1333

Nicotinate and nicotinamide metabolism

6 of 6

2.53

5.39

2.31e-11

CL:1331

Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

7 of 16

2.17

4.93

1.08e-11

CL:1362

Mixed, incl. GDP metabolic process, and Cytidyltransferase-like domain

2 of 6

2.06

0.77

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mtt00760

Nicotinate and nicotinamide metabolism

10 of 15

2.36

8.53

2.54e-20

mtt01100

Metabolic pathways

10 of 566

0.78

0.77

3.44e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

4 of 45

1.48

1.2

0.0016

KW-0328

Glycosyltransferase

3 of 27

1.58

1.01

0.0072

KW-0662

Pyridine nucleotide biosynthesis

2 of 7

1.99

0.92

0.0184

KW-0547

Nucleotide-binding

5 of 286

0.78

0.45

0.0349

KW-0808

Transferase

6 of 436

0.67

0.4

0.0349

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04095

Nicotinate phosphoribosyltransferase (NAPRTase) family

2 of 2

2.53

0.88

0.0248

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036068

Nicotinate phosphoribosyltransferase-like, C-terminal

3 of 3

2.53

1.79

0.00049

IPR041525

Nicotinate/nicotinamide phosphoribosyltransferase

2 of 2

2.53

0.83

0.0310

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