node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clim_0303 | Clim_0322 | Clim_0303 | Clim_0322 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: cph:Cpha266_0372 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.539 |
Clim_0303 | truA | Clim_0303 | Clim_0964 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: cph:Cpha266_0372 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.463 |
Clim_0322 | Clim_0303 | Clim_0322 | Clim_0303 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: cph:Cpha266_0372 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | 0.539 |
Clim_0322 | Clim_1985 | Clim_0322 | Clim_1985 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.996 |
Clim_0322 | Clim_2141 | Clim_0322 | Clim_2141 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | KEGG: plt:Plut_0268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HppK; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | 0.597 |
Clim_0322 | folD | Clim_0322 | Clim_1112 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.584 |
Clim_0322 | folE | Clim_0322 | Clim_0859 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | PFAM: GTP cyclohydrolase I; KEGG: cph:Cpha266_0976 GTP cyclohydrolase I. | 0.597 |
Clim_0322 | glyA | Clim_0322 | Clim_1965 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.729 |
Clim_0322 | guaA | Clim_0322 | Clim_0241 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.590 |
Clim_0322 | purH | Clim_0322 | Clim_1749 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | KEGG: cch:Cag_0258 AICAR transformylase/IMP cyclohydrolase PurH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.506 |
Clim_0322 | ruvA | Clim_0322 | Clim_0321 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.633 |
Clim_0322 | truA | Clim_0322 | Clim_0964 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.584 |
Clim_1985 | Clim_0322 | Clim_1985 | Clim_0322 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.996 |
Clim_1985 | Clim_2141 | Clim_1985 | Clim_2141 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | KEGG: plt:Plut_0268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HppK; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | 0.999 |
Clim_1985 | folD | Clim_1985 | Clim_1112 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.469 |
Clim_1985 | folE | Clim_1985 | Clim_0859 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | PFAM: GTP cyclohydrolase I; KEGG: cph:Cpha266_0976 GTP cyclohydrolase I. | 0.983 |
Clim_1985 | glyA | Clim_1985 | Clim_1965 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.421 |
Clim_2141 | Clim_0322 | Clim_2141 | Clim_0322 | KEGG: plt:Plut_0268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HppK; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: cph:Cpha266_0391 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.597 |
Clim_2141 | Clim_1985 | Clim_2141 | Clim_1985 | KEGG: plt:Plut_0268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HppK; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
Clim_2141 | folE | Clim_2141 | Clim_0859 | KEGG: plt:Plut_0268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HppK; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | PFAM: GTP cyclohydrolase I; KEGG: cph:Cpha266_0976 GTP cyclohydrolase I. | 0.997 |