STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (196 aa)    
Predicted Functional Partners:
Cvib_0140
TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: plt:Plut_0079 orotidine 5'-phosphate decarboxylase subfamily 2.
  
 
 0.988
pyrD
Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
  
 0.973
Cvib_1724
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
  
 0.973
Cvib_0327
Dihydroorotate oxidase B, electron transfer subunit; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: plt:Plut_0262 dihydroorotate dehydrogenase, electron transfer subunit.
  
 
 0.961
pyrB
KEGG: plt:Plut_0492 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.885
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
  
 0.885
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
 
 0.868
carA
TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: plt:Plut_0156 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family.
  
  
 0.866
nadK
NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
     
 0.807
Cvib_1692
PFAM: Prephenate dehydrogenase; KEGG: plt:Plut_2049 prephenate dehydrogenase.
       0.794
Your Current Organism:
Chlorobium phaeovibrioides
NCBI taxonomy Id: 290318
Other names: C. phaeovibrioides DSM 265, Chlorobium phaeovibrioides DSM 265, Chlorobium vibrioforme f. thiosulfatophilum DSM 265, Prosthecochloris vibrioformis DSM 265
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