STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (803 aa)    
Predicted Functional Partners:
Cvib_1453
KEGG: plt:Plut_1667 ATP-requiring DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like.
 
 0.988
Cvib_0182
TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: plt:Plut_0115 single-strand binding protein.
  
 
 0.978
Cvib_0326
TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: plt:Plut_0261 single-strand binding protein.
  
 
 0.978
Cvib_0558
PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: plt:Plut_0502 glutamate synthase (ferredoxin).
  
  
 0.975
leuS
TIGRFAM: leucyl-tRNA synthetase; KEGG: plt:Plut_1636 leucyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.957
Cvib_1407
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: plt:Plut_1617 pyruvate:ferredoxin (flavodoxin) oxidoreductase.
  
   0.940
Cvib_0123
KEGG: plt:Plut_0531 hypothetical protein.
  
 
 0.936
Cvib_1597
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: plt:Plut_1954 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.
  
   0.920
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.870
Cvib_1131
PFAM: SMC domain protein; KEGG: dps:DP0526 related to ATP-dependent dsDNA exonuclease (SbcC).
  
 0.802
Your Current Organism:
Chlorobium phaeovibrioides
NCBI taxonomy Id: 290318
Other names: C. phaeovibrioides DSM 265, Chlorobium phaeovibrioides DSM 265, Chlorobium vibrioforme f. thiosulfatophilum DSM 265, Prosthecochloris vibrioformis DSM 265
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