Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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dapFHypothetical protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa)    
Predicted Functional Partners:
CKO_00152
Hypothetical protein; KEGG: azo:azo0595 6.1e-05 3',5'-cyclic-nucleotide phosphodiesterase K01120; COG: COG3159 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score:8.96.
  
    0.977
lysA
Hypothetical protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
 0.973
dapE
Hypothetical protein; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.
 
  
 0.958
xerC
Hypothetical protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the to [...]
  
  
 0.950
murE
Hypothetical protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
  
 0.948
CKO_04200
Hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family.
 
 
 0.923
carB
Hypothetical protein; KEGG: stm:STM0067 0. carB; carbamoyl-phosphate synthase, large subunit K01955; COG: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family.
      0.835
CKO_00154
Hypothetical protein; KEGG: bur:Bcep18194_B2556 9.3e-26 HAD-superfamily hydrolase, subfamily IA, variant 1 K01560; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: Cytoplasmic, score:8.96.
  
    0.830
CKO_00150
Hypothetical protein; COG: COG5567 Predicted small periplasmic lipoprotein.
  
  
 0.758
dapA
Hypothetical protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.752
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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