node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKO_00681 | CKO_00682 | CKO_00681 | CKO_00682 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; KEGG: reh:H16_B1289 5.2e-16 phnF; regulator of phosphonate operon, GntR-family; COG: COG2188 Transcriptional regulators; Psort location: Cytoplasmic, score:8.96. | 0.721 |
CKO_00681 | CKO_02994 | CKO_00681 | CKO_02994 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | 0.766 |
CKO_00681 | CKO_02995 | CKO_00681 | CKO_02995 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | COG: COG2104 Sulfur transfer protein involved in thiamine biosynthesis. | 0.865 |
CKO_00681 | CKO_02997 | CKO_00681 | CKO_02997 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; KEGG: mac:MA0154 8.9e-13 bioB; biotin synthase K01012; COG: COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. | 0.640 |
CKO_00681 | thiC | CKO_00681 | CKO_02992 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.992 |
CKO_00681 | thiE | CKO_00681 | CKO_02993 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
CKO_00681 | thiG | CKO_00681 | CKO_02996 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.933 |
CKO_00681 | thiM | CKO_00681 | CKO_00680 | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.998 |
CKO_00682 | CKO_00681 | CKO_00682 | CKO_00681 | Hypothetical protein; KEGG: reh:H16_B1289 5.2e-16 phnF; regulator of phosphonate operon, GntR-family; COG: COG2188 Transcriptional regulators; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | 0.721 |
CKO_00682 | thiM | CKO_00682 | CKO_00680 | Hypothetical protein; KEGG: reh:H16_B1289 5.2e-16 phnF; regulator of phosphonate operon, GntR-family; COG: COG2188 Transcriptional regulators; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.672 |
CKO_00687 | thiM | CKO_00687 | CKO_00680 | Hypothetical protein; KEGG: eco:b2097 1.6e-181 fbaB, dhnA; fructose-bisphosphate aldolase class I K01623; COG: COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. | Hypothetical protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.574 |
CKO_02994 | CKO_00681 | CKO_02994 | CKO_00681 | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | 0.766 |
CKO_02994 | CKO_02995 | CKO_02994 | CKO_02995 | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | COG: COG2104 Sulfur transfer protein involved in thiamine biosynthesis. | 0.999 |
CKO_02994 | CKO_02997 | CKO_02994 | CKO_02997 | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Hypothetical protein; KEGG: mac:MA0154 8.9e-13 bioB; biotin synthase K01012; COG: COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. | 0.983 |
CKO_02994 | thiC | CKO_02994 | CKO_02992 | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Hypothetical protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.978 |
CKO_02994 | thiE | CKO_02994 | CKO_02993 | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Hypothetical protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.981 |
CKO_02994 | thiG | CKO_02994 | CKO_02996 | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Hypothetical protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.988 |
CKO_02994 | thiM | CKO_02994 | CKO_00680 | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Hypothetical protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.605 |
CKO_02995 | CKO_00681 | CKO_02995 | CKO_00681 | COG: COG2104 Sulfur transfer protein involved in thiamine biosynthesis. | Hypothetical protein; KEGG: ece:Z3267 4.7e-134 thiD; phosphomethylpyrimidine kinase K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Psort location: Cytoplasmic, score:8.96. | 0.865 |
CKO_02995 | CKO_02994 | CKO_02995 | CKO_02994 | COG: COG2104 Sulfur transfer protein involved in thiamine biosynthesis. | Hypothetical protein; KEGG: eci:UTI89_C3827 1.2e-114 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | 0.999 |