| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CKO_00146 | CKO_00944 | CKO_00146 | CKO_00944 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | 0.878 |
| CKO_00146 | CKO_02807 | CKO_00146 | CKO_02807 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; KEGG: stm:STM0372 1.2e-165 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | 0.878 |
| CKO_00146 | cysG | CKO_00146 | CKO_04792 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.955 |
| CKO_00146 | hemA | CKO_00146 | CKO_01274 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.547 |
| CKO_00146 | hemC | CKO_00146 | CKO_00147 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
| CKO_00146 | hemE | CKO_00146 | CKO_02989 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.940 |
| CKO_00146 | hemL | CKO_00146 | CKO_03214 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; KEGG: sbo:SBO_0143 1.2e-183 hemL; glutamate-1-semialdehyde aminotransferase K01845; COG: COG0001 Glutamate-1-semialdehyde aminotransferase; Psort location: Cytoplasmic, score:8.96. | 0.452 |
| CKO_00809 | CKO_00944 | CKO_00809 | CKO_00944 | Hypothetical protein; KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | 0.626 |
| CKO_00809 | CKO_02807 | CKO_00809 | CKO_02807 | Hypothetical protein; KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; KEGG: stm:STM0372 1.2e-165 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | 0.624 |
| CKO_00809 | cysG | CKO_00809 | CKO_04792 | Hypothetical protein; KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.627 |
| CKO_00809 | hemA | CKO_00809 | CKO_01274 | Hypothetical protein; KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.542 |
| CKO_00809 | hemC | CKO_00809 | CKO_00147 | Hypothetical protein; KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.852 |
| CKO_00809 | hemL | CKO_00809 | CKO_03214 | Hypothetical protein; KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; KEGG: sbo:SBO_0143 1.2e-183 hemL; glutamate-1-semialdehyde aminotransferase K01845; COG: COG0001 Glutamate-1-semialdehyde aminotransferase; Psort location: Cytoplasmic, score:8.96. | 0.529 |
| CKO_00944 | CKO_00146 | CKO_00944 | CKO_00146 | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.878 |
| CKO_00944 | CKO_00809 | CKO_00944 | CKO_00809 | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | Hypothetical protein; KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: Cytoplasmic, score:8.96. | 0.626 |
| CKO_00944 | CKO_00946 | CKO_00944 | CKO_00946 | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | Hypothetical protein; KEGG: rde:RD1_3144 3.9e-18 fructosyl-amino acid oxidase, putative; COG: COG0665 Glycine/D-amino acid oxidases (deaminating). | 0.492 |
| CKO_00944 | CKO_02807 | CKO_00944 | CKO_02807 | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | Hypothetical protein; KEGG: stm:STM0372 1.2e-165 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | 0.910 |
| CKO_00944 | cysG | CKO_00944 | CKO_04792 | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | Hypothetical protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.874 |
| CKO_00944 | hemA | CKO_00944 | CKO_01274 | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | Hypothetical protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.844 |
| CKO_00944 | hemC | CKO_00944 | CKO_00147 | Hypothetical protein; KEGG: eca:ECA0203 2.5e-103 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score:8.96; Belongs to the ALAD family. | Hypothetical protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |