STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpXHypothetical protein; KEGG: stm:STM1844 2.4e-146 htpX; heat shock protein, integral membrane protein K03799; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the peptidase M48B family. (293 aa)    
Predicted Functional Partners:
CKO_03760
Hypothetical protein; KEGG: reh:H16_A0378 0.0039 predicted GTPase K01529; COG: COG0699 Predicted GTPases (dynamin-related).
     
 0.745
CKO_02096
COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the BI1 family.
  
  
 0.673
CKO_02648
Hypothetical protein; KEGG: eci:UTI89_C0527 1.5e-137 ybbN; putative thioredoxin-like protein K05838; COG: COG3118 Thioredoxin domain-containing protein; Psort location: Cytoplasmic, score:9.26.
  
  
 0.641
grpE
Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...]
  
  
 0.616
ftsH
Hypothetical protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 
 0.615
CKO_01120
COG: COG2979 Uncharacterized protein conserved in bacteria.
   
    0.575
dnaJ
Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, Dna [...]
  
 
 0.554
lon
Hypothetical protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
   
 
 0.530
CKO_01143
Hypothetical protein; KEGG: stm:STM1845 0. prc; carboxy-terminal protease for penicillin-binding protein 3 K03797; COG: COG0793 Periplasmic protease; Belongs to the peptidase S41A family.
     
 0.510
CKO_03695
COG: COG3030 Protein affecting phage T7 exclusion by the F plasmid; Psort location: CytoplasmicMembrane, score:10.00.
   
  
 0.510
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.