Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tolRHypothetical protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa)    
Predicted Functional Partners:
tolQ
Hypothetical protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
 
 
 0.999
CKO_04401
Hypothetical protein; COG: COG0811 Biopolymer transport proteins; Psort location: CytoplasmicMembrane, score:10.00.
 
 
 0.984
tolB
Hypothetical protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
  
 0.977
CKO_01329
Hypothetical protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 0.954
CKO_00040
COG: COG0810 Periplasmic protein TonB, links inner and outer membranes; Psort location: CytoplasmicMembrane, score:8.02.
  
 
 0.942
CKO_02405
Hypothetical protein; KEGG: eci:UTI89_C0732 5.9e-63 ybgC; cytoplasmic Tol-Pal protein; COG: COG0824 Predicted thioesterase.
  
  
 0.905
pal
Hypothetical protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.887
CKO_02402
Hypothetical protein; KEGG: eci:UTI89_C0735 1.0e-83 tolA; membrane spanning protein TolA K03646; COG: COG3064 Membrane protein involved in colicin uptake; Psort location: CytoplasmicMembrane, score:8.02.
 
 
 0.794
cpoB
Hypothetical protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family.
 
  
 0.733
bamA
Hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
  
   
 0.723
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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