STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnDHypothetical protein; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (890 aa)    
Predicted Functional Partners:
CKO_00234
COG: COG0347 Nitrogen regulatory protein PII; Psort location: Cytoplasmic, score:8.96; Belongs to the P(II) protein family.
 
 
 0.987
CKO_02708
COG: COG0347 Nitrogen regulatory protein PII; Psort location: Cytoplasmic, score:8.96; Belongs to the P(II) protein family.
 
 
 
 0.886
glnE
Hypothetical protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]
 
   
 0.776
dapD
Hypothetical protein; KEGG: spt:SPA0219 1.1e-141 dapD; 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase K00674; COG: COG2171 Tetrahydrodipicolinate N-succinyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the transferase hexapeptide repeat family.
     
 0.768
CKO_04620
Hypothetical protein; KEGG: sbo:SBO_3170 0. gltB; glutamate synthase, large subunit K00265; COG: COG0069 Glutamate synthase domain 2; Psort location: Cytoplasmic, score:8.96.
 
   
 0.675
map
Hypothetical protein; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.615
CKO_03143
Hypothetical protein; KEGG: stm:STM4006 3.3e-172 glnL; sensory kinase (phosphatase) in two-component regulatory system with GlnG (nitrogen regulator II, NRII) K07708; COG: COG3852 Signal transduction histidine kinase, nitrogen specific; Psort location: CytoplasmicMembrane, score:7.88.
  
 
 
 0.583
CKO_02707
Hypothetical protein; KEGG: ter:Tery_3993 2.5e-36 adenylate/guanylate cyclase K01769; COG: COG0004 Ammonia permease; Psort location: CytoplasmicMembrane, score:10.00.
 
   
 0.535
CKO_03204
Hypothetical protein; COG: NOG09673 non supervised orthologous group; Psort location: Cytoplasmic, score:8.96; Belongs to the UPF0325 family.
       0.531
cbiA
Hypothetical protein; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
   
    0.520
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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