| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CKO_02041 | betI | CKO_02041 | CKO_02582 | Hypothetical protein; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Hypothetical protein; Repressor involved in choline regulation of the bet genes. | 0.417 |
| CKO_02041 | caiT | CKO_02041 | CKO_03343 | Hypothetical protein; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Hypothetical protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. | 0.513 |
| CKO_03340 | caiA | CKO_03340 | CKO_03344 | Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. | Hypothetical protein; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. | 0.995 |
| CKO_03340 | caiB | CKO_03340 | CKO_03345 | Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. | Hypothetical protein; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. Belongs to the CoA-transferase III family. CaiB subfamily. | 0.816 |
| CKO_03340 | caiC | CKO_03340 | CKO_03346 | Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. | Hypothetical protein; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. | 0.711 |
| CKO_03340 | caiD | CKO_03340 | CKO_03347 | Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. | Hypothetical protein; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA. | 0.835 |
| CKO_03340 | caiT | CKO_03340 | CKO_03343 | Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. | Hypothetical protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. | 0.486 |
| CKO_03340 | fixA | CKO_03340 | CKO_03341 | Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. | Hypothetical protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. | 0.996 |
| CKO_03342 | caiA | CKO_03342 | CKO_03344 | Hypothetical protein. | Hypothetical protein; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. | 0.586 |
| CKO_03342 | caiB | CKO_03342 | CKO_03345 | Hypothetical protein. | Hypothetical protein; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. Belongs to the CoA-transferase III family. CaiB subfamily. | 0.441 |
| CKO_03342 | caiT | CKO_03342 | CKO_03343 | Hypothetical protein. | Hypothetical protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. | 0.682 |
| CKO_03342 | fixA | CKO_03342 | CKO_03341 | Hypothetical protein. | Hypothetical protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. | 0.457 |
| betA | betI | CKO_02584 | CKO_02582 | Hypothetical protein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Hypothetical protein; Repressor involved in choline regulation of the bet genes. | 0.975 |
| betA | caiT | CKO_02584 | CKO_03343 | Hypothetical protein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Hypothetical protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. | 0.565 |
| betI | CKO_02041 | CKO_02582 | CKO_02041 | Hypothetical protein; Repressor involved in choline regulation of the bet genes. | Hypothetical protein; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.417 |
| betI | betA | CKO_02582 | CKO_02584 | Hypothetical protein; Repressor involved in choline regulation of the bet genes. | Hypothetical protein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | 0.975 |
| betI | caiT | CKO_02582 | CKO_03343 | Hypothetical protein; Repressor involved in choline regulation of the bet genes. | Hypothetical protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. | 0.495 |
| caiA | CKO_03340 | CKO_03344 | CKO_03340 | Hypothetical protein; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. | Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. | 0.995 |
| caiA | CKO_03342 | CKO_03344 | CKO_03342 | Hypothetical protein; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. | Hypothetical protein. | 0.586 |
| caiA | caiB | CKO_03344 | CKO_03345 | Hypothetical protein; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. | Hypothetical protein; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. Belongs to the CoA-transferase III family. CaiB subfamily. | 0.979 |
