| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CKO_00500 | CKO_00587 | CKO_00500 | CKO_00587 | COG: COG3092 Uncharacterized protein conserved in bacteria. | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | 0.765 |
| CKO_00500 | CKO_04561 | CKO_00500 | CKO_04561 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; May be involved in cell division. | 0.679 |
| CKO_00500 | lptC | CKO_00500 | CKO_04602 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.692 |
| CKO_00500 | metJ | CKO_00500 | CKO_03057 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.749 |
| CKO_00500 | mutH | CKO_00500 | CKO_04202 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.742 |
| CKO_00500 | proQ | CKO_00500 | CKO_01142 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.756 |
| CKO_00500 | rraB | CKO_00500 | CKO_03550 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.748 |
| CKO_00500 | seqA | CKO_00500 | CKO_02472 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.745 |
| CKO_00500 | syd | CKO_00500 | CKO_04149 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.751 |
| CKO_00500 | yihI | CKO_00500 | CKO_03146 | COG: COG3092 Uncharacterized protein conserved in bacteria. | Hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.783 |
| CKO_00587 | CKO_00500 | CKO_00587 | CKO_00500 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | COG: COG3092 Uncharacterized protein conserved in bacteria. | 0.765 |
| CKO_00587 | CKO_04561 | CKO_00587 | CKO_04561 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; May be involved in cell division. | 0.738 |
| CKO_00587 | lptC | CKO_00587 | CKO_04602 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.718 |
| CKO_00587 | metJ | CKO_00587 | CKO_03057 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.743 |
| CKO_00587 | mutH | CKO_00587 | CKO_04202 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.738 |
| CKO_00587 | proQ | CKO_00587 | CKO_01142 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.765 |
| CKO_00587 | rraB | CKO_00587 | CKO_03550 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.763 |
| CKO_00587 | seqA | CKO_00587 | CKO_02472 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.774 |
| CKO_00587 | syd | CKO_00587 | CKO_04149 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.697 |
| CKO_00587 | yihI | CKO_00587 | CKO_03146 | COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family. | Hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.733 |