node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKO_00709 | clpP | CKO_00709 | CKO_02723 | Hypothetical protein; KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone. | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.707 |
CKO_00709 | dnaJ | CKO_00709 | CKO_03371 | Hypothetical protein; KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, Dna [...] | 0.949 |
CKO_00709 | groL | CKO_00709 | CKO_03692 | Hypothetical protein; KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone. | Hypothetical protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.944 |
CKO_00709 | groS | CKO_00709 | CKO_03693 | Hypothetical protein; KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone. | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.903 |
CKO_00709 | grpE | CKO_00709 | CKO_03936 | Hypothetical protein; KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.956 |
CKO_00709 | htpG | CKO_00709 | CKO_02676 | Hypothetical protein; KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone. | Hypothetical protein; Molecular chaperone. Has ATPase activity. | 0.967 |
CKO_02852 | clpP | CKO_02852 | CKO_02723 | Hypothetical protein; COG: NOG08675 non supervised orthologous group. | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.707 |
CKO_02852 | dnaJ | CKO_02852 | CKO_03371 | Hypothetical protein; COG: NOG08675 non supervised orthologous group. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, Dna [...] | 0.923 |
CKO_02852 | groL | CKO_02852 | CKO_03692 | Hypothetical protein; COG: NOG08675 non supervised orthologous group. | Hypothetical protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.938 |
CKO_02852 | groS | CKO_02852 | CKO_03693 | Hypothetical protein; COG: NOG08675 non supervised orthologous group. | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.893 |
CKO_02852 | grpE | CKO_02852 | CKO_03936 | Hypothetical protein; COG: NOG08675 non supervised orthologous group. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.952 |
CKO_02852 | htpG | CKO_02852 | CKO_02676 | Hypothetical protein; COG: NOG08675 non supervised orthologous group. | Hypothetical protein; Molecular chaperone. Has ATPase activity. | 0.967 |
CKO_04076 | groL | CKO_04076 | CKO_03692 | Hypothetical protein; KEGG: eci:UTI89_C3084 0. hycE; formate hydrogenlyase subunit 5 precursor; COG: COG3261 Ni,Fe-hydrogenase III large subunit; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.922 |
clpP | CKO_00709 | CKO_02723 | CKO_00709 | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone. | 0.707 |
clpP | CKO_02852 | CKO_02723 | CKO_02852 | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; COG: NOG08675 non supervised orthologous group. | 0.707 |
clpP | dnaJ | CKO_02723 | CKO_03371 | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, Dna [...] | 0.607 |
clpP | dnaK | CKO_02723 | CKO_03373 | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.717 |
clpP | groL | CKO_02723 | CKO_03692 | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.924 |
clpP | groS | CKO_02723 | CKO_03693 | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.894 |
clpP | grpE | CKO_02723 | CKO_03936 | Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.787 |