close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CKO_03809Hypothetical protein; KEGG: stm:STM4281 1.2e-253 nrfE; putative methylase K04016; COG: COG1138 Cytochrome c biogenesis factor; Psort location: CytoplasmicMembrane, score:10.00. (555 aa)    
Predicted Functional Partners:
CKO_03808
Hypothetical protein; Possible subunit of a heme lyase.
  
 0.995
CKO_03807
Hypothetical protein; KEGG: eci:UTI89_C4062 2.0e-06 yhjL; cellulose synthase operon protein C K00694; COG: COG4235 Cytochrome c biogenesis factor.
 
 
 0.989
CKO_00583
Hypothetical protein; Possible subunit of a heme lyase.
 
 0.982
CKO_00582
KEGG: azo:azo3929 3.3e-30 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Periplasmic, score:9.76.
 
  
 0.945
ccmE
Hypothetical protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.932
CKO_03810
Hypothetical protein; KEGG: pai:PAE2861 9.2e-19 molybdopterin oxidoreductase, membrane subunit K00185; COG: COG3301 Formate-dependent nitrite reductase, membrane component; Psort location: CytoplasmicMembrane, score:10.00.
 
  
 0.889
ccmC
Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
  
 0.880
CKO_00575
Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
  
 0.874
ccmA
Hypothetical protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
   
 0.858
CKO_02051
Hypothetical protein; KEGG: reh:H16_A0306 5.1e-09 bcp; peroxiredoxin K00435; COG: COG0526 Thiol-disulfide isomerase and thioredoxins.
 
  
 0.806
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.