CKO_04067 protein (Citrobacter koseri) - STRING interaction network

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CKO_04067

Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (780 aa)

Predicted Functional Partners:

CKO_04086

0.986

CKO_04085

0.895

CKO_04384

0.886

CKO_04084

0.872

CKO_04388

0.851

CKO_04083

0.843

hybF

0.840

CKO_04391

0.838

hypA

0.836

CKO_04387

0.836

Your Current Organism:

Citrobacter koseri

NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CKO_04067	CKO_04083	CKO_04067	CKO_04083	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	0.843
CKO_04067	CKO_04084	CKO_04067	CKO_04084	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; COG: COG0298 Hydrogenase maturation factor.	0.872
CKO_04067	CKO_04085	CKO_04067	CKO_04085	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; COG: COG0409 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96; Belongs to the HypD family.	0.895
CKO_04067	CKO_04086	CKO_04067	CKO_04086	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; KEGG: cch:Cag_0556 2.2e-79 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96.	0.986
CKO_04067	CKO_04384	CKO_04067	CKO_04384	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; COG: COG0298 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96.	0.886
CKO_04067	CKO_04387	CKO_04067	CKO_04387	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; KEGG: sfx:S3241 4.8e-77 hybD; hydrogenase-2 component K08567; COG: COG0680 Ni,Fe-hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96.	0.836
CKO_04067	CKO_04388	CKO_04067	CKO_04388	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; KEGG: ecc:c3731 1.3e-298 hybC; hydrogenase-2 large chain precursor K06281; COG: COG0374 Ni,Fe-hydrogenase I large subunit; Psort location: Periplasmic, score:9.44; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.851
CKO_04067	CKO_04391	CKO_04067	CKO_04391	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; KEGG: sty:STY3321 1.0e-202 hyb0; hydrogenase small chain K06282; COG: COG1740 Ni,Fe-hydrogenase I small subunit; Psort location: Periplasmic, score:9.76.	0.838
CKO_04067	hybF	CKO_04067	CKO_04385	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.840
CKO_04067	hypA	CKO_04067	CKO_04082	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.836
CKO_04083	CKO_04067	CKO_04083	CKO_04067	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	0.843
CKO_04083	CKO_04084	CKO_04083	CKO_04084	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; COG: COG0298 Hydrogenase maturation factor.	0.983
CKO_04083	CKO_04085	CKO_04083	CKO_04085	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; COG: COG0409 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96; Belongs to the HypD family.	0.993
CKO_04083	CKO_04086	CKO_04083	CKO_04086	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; KEGG: cch:Cag_0556 2.2e-79 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96.	0.966
CKO_04083	CKO_04384	CKO_04083	CKO_04384	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; COG: COG0298 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96.	0.966
CKO_04083	CKO_04387	CKO_04083	CKO_04387	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; KEGG: sfx:S3241 4.8e-77 hybD; hydrogenase-2 component K08567; COG: COG0680 Ni,Fe-hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96.	0.826
CKO_04083	CKO_04388	CKO_04083	CKO_04388	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; KEGG: ecc:c3731 1.3e-298 hybC; hydrogenase-2 large chain precursor K06281; COG: COG0374 Ni,Fe-hydrogenase I large subunit; Psort location: Periplasmic, score:9.44; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.833
CKO_04083	CKO_04391	CKO_04083	CKO_04391	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; KEGG: sty:STY3321 1.0e-202 hyb0; hydrogenase small chain K06282; COG: COG1740 Ni,Fe-hydrogenase I small subunit; Psort location: Periplasmic, score:9.76.	0.895
CKO_04083	hybF	CKO_04083	CKO_04385	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.932
CKO_04083	hypA	CKO_04083	CKO_04082	Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97.	Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.992

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