| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CKO_04067 | CKO_04083 | CKO_04067 | CKO_04083 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | 0.872 |
| CKO_04067 | CKO_04084 | CKO_04067 | CKO_04084 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; COG: COG0298 Hydrogenase maturation factor. | 0.870 |
| CKO_04067 | CKO_04085 | CKO_04067 | CKO_04085 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; COG: COG0409 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96; Belongs to the HypD family. | 0.921 |
| CKO_04067 | CKO_04086 | CKO_04067 | CKO_04086 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; KEGG: cch:Cag_0556 2.2e-79 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96. | 0.986 |
| CKO_04067 | CKO_04384 | CKO_04067 | CKO_04384 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; COG: COG0298 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96. | 0.916 |
| CKO_04067 | CKO_04387 | CKO_04067 | CKO_04387 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; KEGG: sfx:S3241 4.8e-77 hybD; hydrogenase-2 component K08567; COG: COG0680 Ni,Fe-hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96. | 0.867 |
| CKO_04067 | CKO_04388 | CKO_04067 | CKO_04388 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; KEGG: ecc:c3731 1.3e-298 hybC; hydrogenase-2 large chain precursor K06281; COG: COG0374 Ni,Fe-hydrogenase I large subunit; Psort location: Periplasmic, score:9.44; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.877 |
| CKO_04067 | hybF | CKO_04067 | CKO_04385 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.867 |
| CKO_04067 | hypA | CKO_04067 | CKO_04082 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.865 |
| CKO_04067 | ureG | CKO_04067 | CKO_04460 | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | Hypothetical protein; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. | 0.438 |
| CKO_04083 | CKO_04067 | CKO_04083 | CKO_04067 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.872 |
| CKO_04083 | CKO_04084 | CKO_04083 | CKO_04084 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; COG: COG0298 Hydrogenase maturation factor. | 0.980 |
| CKO_04083 | CKO_04085 | CKO_04083 | CKO_04085 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; COG: COG0409 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96; Belongs to the HypD family. | 0.995 |
| CKO_04083 | CKO_04086 | CKO_04083 | CKO_04086 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; KEGG: cch:Cag_0556 2.2e-79 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96. | 0.976 |
| CKO_04083 | CKO_04384 | CKO_04083 | CKO_04384 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; COG: COG0298 Hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96. | 0.966 |
| CKO_04083 | CKO_04387 | CKO_04083 | CKO_04387 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; KEGG: sfx:S3241 4.8e-77 hybD; hydrogenase-2 component K08567; COG: COG0680 Ni,Fe-hydrogenase maturation factor; Psort location: Cytoplasmic, score:8.96. | 0.814 |
| CKO_04083 | CKO_04388 | CKO_04083 | CKO_04388 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; KEGG: ecc:c3731 1.3e-298 hybC; hydrogenase-2 large chain precursor K06281; COG: COG0374 Ni,Fe-hydrogenase I large subunit; Psort location: Periplasmic, score:9.44; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.830 |
| CKO_04083 | hybF | CKO_04083 | CKO_04385 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.964 |
| CKO_04083 | hypA | CKO_04083 | CKO_04082 | Hypothetical protein; KEGG: reh:H16_A1087 9.9e-14 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: Cytoplasmic, score:9.97. | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.998 |
| CKO_04084 | CKO_04067 | CKO_04084 | CKO_04067 | Hypothetical protein; COG: COG0298 Hydrogenase maturation factor. | Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.870 |
