close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
queEHypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa)    
Predicted Functional Partners:
queC
Hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 0.996
CKO_04120
Hypothetical protein; KEGG: sec:SC2880 4.7e-63 ptpS; putative synthase K01737; COG: COG0720 6-pyruvoyl-tetrahydropterin synthase; Psort location: Cytoplasmic, score:8.96.
 
 
 0.991
queF
Hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
  
  
 0.900
CKO_03411
Hypothetical protein; COG: NOG06143 non supervised orthologous group; Psort location: Cytoplasmic, score:8.96.
  
 
 0.876
CKO_03507
Hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
  
  
 0.876
CKO_03580
Hypothetical protein; KEGG: spt:SPA4252 0. nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score:8.96.
  
 
 0.876
CKO_00935
Hypothetical protein; KEGG: shn:Shewana3_2424 1.6e-55 isocitrate dehydrogenase (NADP(+)) K00031; COG: NOG08609 non supervised orthologous group; Psort location: Cytoplasmic, score:8.96.
  
  
 0.869
CKO_00587
COG: COG3082 Uncharacterized protein conserved in bacteria; Belongs to the UPF0352 family.
  
     0.655
seqA
Hypothetical protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.604
cysD
Hypothetical protein; KEGG: ecp:ECP_2734 3.9e-162 sulfate adenylyltransferase subunit 2 K00957; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: Cytoplasmic, score:8.96.
      
 0.581
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
Server load: medium (42%) [HD]