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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CKO_04151Hypothetical protein; KEGG: hch:HCH_00651 4.5e-129 predicted Rossmann fold nucleotide-binding protein K00052; COG: COG1611 Predicted Rossmann fold nucleotide-binding protein; Psort location: Cytoplasmic, score:8.96. (444 aa)    
Predicted Functional Partners:
CKO_04822
Hypothetical protein; KEGG: rso:RSc2880 1.3e-07 gph, RS00222; probable phosphoglycolate phosphatase protein K01091; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: Cytoplasmic, score:8.96.
 
  
  0.916
amn
Hypothetical protein; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.
   
 
 0.914
apt
Hypothetical protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
 0.912
surE
Hypothetical protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
    
  0.911
adk
Hypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
    
  0.910
CKO_01840
Hypothetical protein; KEGG: ssn:SSO_1149 2.9e-237 purB; adenylosuccinate lyase K01756; COG: COG0015 Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
  0.906
cpdA
Hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
    
  0.903
CKO_03418
Hypothetical protein; KEGG: spt:SPA4373 3.0e-107 yjjG; hypothetical protein K08723; COG: COG1011 Predicted hydrolase (HAD superfamily).
    
  0.902
CKO_00715
Hypothetical protein; KEGG: sty:STY2335 1.6e-53 udk; uridine kinase K00876; COG: COG0572 Uridine kinase; Psort location: Cytoplasmic, score:8.96.
    
  0.901
cmk
Hypothetical protein; KEGG: eco:b0910 1.4e-111 cmk, mssA, ycaF, ycaG; cytidine monophosphate (CMP) kinase K00945; COG: COG0283 Cytidylate kinase.
     
  0.900
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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