STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CKO_04323Hypothetical protein; COG: COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (187 aa)    
Predicted Functional Partners:
CKO_00541
Hypothetical protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 0.977
CKO_04024
Hypothetical protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 0.974
yqgF
Hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
  
  
 0.971
CKO_03396
Hypothetical protein; KEGG: stm:STM4580.S 1.5e-217 nadR; nicotinamide-nucleotide adenylyltransferase K00952:K06210:K06211; COG: COG3172 Predicted ATPase/kinase involved in NAD metabolism; Psort location: Cytoplasmic, score:8.96.
   
    0.890
CKO_00047
Hypothetical protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...]
  
 
 0.868
dut
Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
  
 0.756
gshB
Hypothetical protein; KEGG: eci:UTI89_C3336 1.9e-162 gshB; glutathione synthetase K01920; COG: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Psort location: Cytoplasmic, score:8.96.
 
   
 0.735
thyA
Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
  
 0.657
CKO_02437
Hypothetical protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
   
    0.655
CKO_04803
Hypothetical protein; COG: NOG06213 non supervised orthologous group; Psort location: Cytoplasmic, score:8.96.
   
    0.617
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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