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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hldEHypothetical protein; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (477 aa)    
Predicted Functional Partners:
gmhA
Hypothetical protein; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
  
 0.990
CKO_03165
Hypothetical protein; KEGG: sty:STY0275 8.4e-96 yaeD; D-glycero-D-manno-heptose 1 phosphatase K03273; COG: COG0241 Histidinol phosphatase and related phosphatases; Psort location: Cytoplasmic, score:8.96.
  
 0.984
hldD
Hypothetical protein; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
 
 
 0.981
diaA
Hypothetical protein; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily.
   
 0.876
CKO_05079
Hypothetical protein; KEGG: ecp:ECP_3720 3.3e-181 ADP-heptose-LPS heptosyltransferase II K02843; COG: COG0859 ADP-heptose:LPS heptosyltransferase.
 
  
 0.835
CKO_05083
Hypothetical protein; KEGG: eca:ECA0160 1.8e-86 waaQ, rfaQ; lipopolysaccharide core biosynthesis glycosyl transferase rfaq K02849; COG: COG0859 ADP-heptose:LPS heptosyltransferase.
 
  
 0.831
CKO_05080
Hypothetical protein; KEGG: sbo:SBO_3626 3.3e-140 rfaC; heptosyl transferase I K02841; COG: COG0859 ADP-heptose:LPS heptosyltransferase.
 
  
 0.806
CKO_02890
Hypothetical protein; KEGG: pmu:PM1844 5.3e-09 rfaF; ADP-heptose--LPS heptosyltransferase II K02843; COG: COG0859 ADP-heptose:LPS heptosyltransferase.
 
  
 0.784
glnE
Hypothetical protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]
       0.644
CKO_04442
Hypothetical protein; KEGG: aha:AHA_3770 5.9e-40 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein.
       0.593
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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