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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CKO_04442Hypothetical protein; KEGG: aha:AHA_3770 5.9e-40 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein. (466 aa)    
Predicted Functional Partners:
CKO_04441
Hypothetical protein.
       0.752
glnE
Hypothetical protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]
       0.730
yihI
Hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family.
  
   
 0.668
CKO_00500
COG: COG3092 Uncharacterized protein conserved in bacteria.
  
     0.611
hldE
Hypothetical protein; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.
       0.593
CKO_04443
COG: COG3103 SH3 domain protein.
       0.583
CKO_00450
Hypothetical protein; KEGG: spt:SPA0477 3.3e-78 sixA; phosphohistidine phosphatase K08296; COG: COG2062 Phosphohistidine phosphatase SixA; Psort location: Cytoplasmic, score:8.96.
 
     0.541
CKO_00588
COG: COG3081 Nucleoid-associated protein; Psort location: Cytoplasmic, score:8.96.
  
   
 0.497
CKO_01388
Hypothetical protein; COG: NOG14122 non supervised orthologous group; Psort location: Cytoplasmic, score:8.96.
  
     0.473
CKO_00586
Hypothetical protein; KEGG: aha:AHA_1664 1.1e-102 putative sulfatase; COG: COG3083 Predicted hydrolase of alkaline phosphatase superfamily; Psort location: CytoplasmicMembrane, score:10.00.
  
     0.471
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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