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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CKO_04443COG: COG3103 SH3 domain protein. (206 aa)    
Predicted Functional Partners:
cca
Hypothetical protein; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
  
  
 0.720
CKO_00210
Hypothetical protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrad [...]
  
  
 0.650
CKO_02987
COG: COG3068 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score:8.96.
  
     0.648
CKO_04501
COG: COG5393 Predicted membrane protein.
  
     0.644
glnE
Hypothetical protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]
 
     0.643
CKO_00144
Hypothetical protein; COG: COG3071 Uncharacterized enzyme of heme biosynthesis.
  
     0.608
CKO_04019
Hypothetical protein; COG: COG4575 Uncharacterized conserved protein.
  
     0.597
CKO_03609
Hypothetical protein; KEGG: bmf:BAB1_0046 2.7e-14 family of unknown function DUF490 K01076; COG: COG2911 Uncharacterized protein conserved in bacteria; Psort location: OuterMembrane, score:9.52.
 
     0.590
CKO_04442
Hypothetical protein; KEGG: aha:AHA_3770 5.9e-40 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein.
       0.583
CKO_00145
Hypothetical protein; KEGG: stm:STM3936 4.6e-182 hemX; uroporphyrinogen III methylase K02496; COG: COG2959 Uncharacterized enzyme of heme biosynthesis.
  
     0.540
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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