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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysGHypothetical protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa)    
Predicted Functional Partners:
hemC
Hypothetical protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.995
cysI
Hypothetical protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.968
CKO_00813
Hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family.
 
 
 0.964
CKO_01293
Hypothetical protein; KEGG: eca:ECA2991 0. nasB; nitrite reductase [NAD(P)H] large subunit K00362; COG: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; Psort location: Cytoplasmic, score:9.26; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 0.962
CKO_00814
Hypothetical protein; KEGG: stm:STM2024 9.6e-111 cbiL; precorrin-2 C20-methyltransferase K03394; COG: COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family.
 
 
 0.960
CKO_00146
Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.955
cysH
Hypothetical protein; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.951
CKO_04790
Hypothetical protein; KEGG: sfl:SF3385 3.8e-52 nirD; nitrite reductase (NAD(P)H) subunit K00363; COG: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; Psort location: Cytoplasmic, score:9.97.
 
  
 0.948
hemE
Hypothetical protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.947
cysC
Hypothetical protein; Catalyzes the synthesis of activated sulfate.
  
  
 0.934
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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