Adeh_0643 protein (Anaeromyxobacter dehalogenans)

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Adeh_0643

Type IV pilus biogenesis protein PilO. (209 aa)

Predicted Functional Partners:

Adeh_0642

0.998

Adeh_0644

0.997

Adeh_0641

0.995

Adeh_0645

0.995

Adeh_2701

0.953

Adeh_0624

0.901

Adeh_0678

0.876

Adeh_0622

0.853

Adeh_0635

0.829

Adeh_0627

0.777

Your Current Organism:

Anaeromyxobacter dehalogenans

NCBI taxonomy Id: 290397
Other names: A. dehalogenans 2CP-C, Anaeromyxobacter dehalogenans 2CP-C, Anaeromyxobacter dehalogenans ATCC BAA-259, Anaeromyxobacter dehalogenans str. 2CP-C, Anaeromyxobacter dehalogenans strain 2CP-C

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Adeh_0622	Adeh_0624	Type II secretion system protein E.	Type II secretion system protein.	0.993
Adeh_0622	Adeh_0635	Type II secretion system protein E.	Fimbrial protein pilin.	0.452
Adeh_0622	Adeh_0641	Type II secretion system protein E.	Type IV pilus assembly protein PilM.	0.940
Adeh_0622	Adeh_0642	Type II secretion system protein E.	Fimbrial assembly.	0.852
Adeh_0622	Adeh_0643	Type II secretion system protein E.	Type IV pilus biogenesis protein PilO.	0.853
Adeh_0622	Adeh_0644	Type II secretion system protein E.	Hypothetical protein.	0.842
Adeh_0622	Adeh_0645	Type II secretion system protein E.	Type II and III secretion system protein, secretin.	0.915
Adeh_0622	Adeh_0678	Type II secretion system protein E.	Fimbrial assembly protein.	0.531
Adeh_0622	Adeh_2701	Type II secretion system protein E.	Peptidoglycan-binding LysM.	0.800
Adeh_0624	Adeh_0622	Type II secretion system protein.	Type II secretion system protein E.	0.993
Adeh_0624	Adeh_0635	Type II secretion system protein.	Fimbrial protein pilin.	0.631
Adeh_0624	Adeh_0641	Type II secretion system protein.	Type IV pilus assembly protein PilM.	0.965
Adeh_0624	Adeh_0642	Type II secretion system protein.	Fimbrial assembly.	0.898
Adeh_0624	Adeh_0643	Type II secretion system protein.	Type IV pilus biogenesis protein PilO.	0.901
Adeh_0624	Adeh_0644	Type II secretion system protein.	Hypothetical protein.	0.849
Adeh_0624	Adeh_0645	Type II secretion system protein.	Type II and III secretion system protein, secretin.	0.935
Adeh_0624	Adeh_0678	Type II secretion system protein.	Fimbrial assembly protein.	0.689
Adeh_0624	Adeh_2701	Type II secretion system protein.	Peptidoglycan-binding LysM.	0.800
Adeh_0627	Adeh_0635	Tfp pilus assembly protein tip-associated adhesin PilY1-like protein.	Fimbrial protein pilin.	0.580
Adeh_0627	Adeh_0641	Tfp pilus assembly protein tip-associated adhesin PilY1-like protein.	Type IV pilus assembly protein PilM.	0.634

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.919

expected number of edges:

11

PPI enrichment p-value:

1.68e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032446

Protein modification by small protein conjugation

7 of 162

1.59

2.48

8.06e-08

GO:0019941

Modification-dependent protein catabolic process

8 of 228

1.5

2.32

4.99e-08

GO:0016567

Protein ubiquitination

6 of 141

1.58

2.17

1.46e-06

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

3 of 13

2.32

2.04

0.00013

GO:0006511

Ubiquitin-dependent protein catabolic process

6 of 219

1.39

1.64

1.56e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

3 of 23

2.07

1.26

0.0039

GO:0030674

Protein-macromolecule adaptor activity

4 of 107

1.53

1.09

0.0039

GO:0019899

Enzyme binding

4 of 147

1.39

0.99

0.0047

GO:0031386

Protein tag

2 of 12

2.18

0.9

0.0214

GO:0005515

Protein binding

6 of 743

0.86

0.56

0.0151

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019005

SCF ubiquitin ligase complex

7 of 17

2.57

6.63

5.21e-14

GO:0000151

Ubiquitin ligase complex

8 of 82

1.94

4.52

2.32e-12

GO:0043224

Nuclear SCF ubiquitin ligase complex

2 of 4

2.65

1.48

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:370

Mixed, incl. Protein neddylation, and SCF ubiquitin ligase complex

7 of 24

2.42

5.88

7.26e-13

CL:373

Protein neddylation, and SCF ubiquitin ligase complex

5 of 17

2.42

4.25

3.95e-09

CL:244

Class I MHC mediated antigen processing & presentation, and Neddylation

8 of 170

1.63

3.0

5.73e-10

CL:394

Nuclear SCF ubiquitin ligase complex, and SKP1 component, POZ domain

3 of 5

2.73

2.66

1.26e-05

CL:408

Mixed, incl. Leucine-rich repeat, cysteine-containing subtype, and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

2 of 5

2.56

1.28

0.0046

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

7 of 119

1.72

3.14

2.18e-09

map04111

Cell cycle - yeast

7 of 122

1.71

3.12

2.18e-09

map04141

Protein processing in endoplasmic reticulum

3 of 176

1.18

0.59

0.0432

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

8 of 114

1.8

3.79

3.23e-11

MAP-983169

Class I MHC mediated antigen processing & presentation

9 of 170

1.68

3.5

8.62e-12

MAP-8951664

Neddylation

6 of 84

1.81

2.97

5.07e-08

MAP-1280218

Adaptive Immune System

9 of 243

1.52

2.84

6.54e-11

MAP-168256

Immune System

9 of 608

1.12

1.43

1.26e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0019005

SCF ubiquitin ligase complex

6 of 20

2.43

5.23

2.59e-11

GOCC:0031461

cullin-RING ubiquitin ligase complex

7 of 45

2.15

4.86

1.13e-11

GOCC:0000151

Ubiquitin ligase complex

8 of 80

1.95

4.48

4.38e-12

GOCC:1902494

Catalytic complex

9 of 747

1.03

1.2

7.79e-07

GOCC:0032991

Protein-containing complex

10 of 2189

0.61

0.51

0.00041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019956

Ubiquitin domain

2 of 6

2.48

0.76

0.0422

IPR019954

Ubiquitin conserved site

2 of 6

2.48

0.76

0.0422

IPR001810

F-box domain

4 of 142

1.4

0.67

0.0374

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00213

Ubiquitin homologues

2 of 16

2.05

0.81

0.0303

SM00256

A Receptor for Ubiquitination Targets

3 of 81

1.52

0.74

0.0303

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