| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Adeh_1822 | Adeh_2003 | Adeh_1822 | Adeh_2003 | Dihydrolipoamide dehydrogenase. | Glycine cleavage H-protein. | 0.926 |
| Adeh_1822 | Adeh_2005 | Adeh_1822 | Adeh_2005 | Dihydrolipoamide dehydrogenase. | Glycine cleavage H-protein. | 0.926 |
| Adeh_1822 | Adeh_2676 | Adeh_1822 | Adeh_2676 | Dihydrolipoamide dehydrogenase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.917 |
| Adeh_1822 | Adeh_4119 | Adeh_1822 | Adeh_4119 | Dihydrolipoamide dehydrogenase. | Glycine cleavage H-protein. | 0.926 |
| Adeh_1822 | folD | Adeh_1822 | Adeh_1247 | Dihydrolipoamide dehydrogenase. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.917 |
| Adeh_1822 | gcvH | Adeh_1822 | Adeh_1244 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.969 |
| Adeh_1822 | gcvPA | Adeh_1822 | Adeh_1243 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.936 |
| Adeh_1822 | gcvPB | Adeh_1822 | Adeh_1242 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.954 |
| Adeh_1822 | gcvT | Adeh_1822 | Adeh_1245 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.965 |
| Adeh_1822 | glyA | Adeh_1822 | Adeh_2744 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
| Adeh_2003 | Adeh_1822 | Adeh_2003 | Adeh_1822 | Glycine cleavage H-protein. | Dihydrolipoamide dehydrogenase. | 0.926 |
| Adeh_2003 | Adeh_2005 | Adeh_2003 | Adeh_2005 | Glycine cleavage H-protein. | Glycine cleavage H-protein. | 0.963 |
| Adeh_2003 | Adeh_2676 | Adeh_2003 | Adeh_2676 | Glycine cleavage H-protein. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.915 |
| Adeh_2003 | Adeh_4119 | Adeh_2003 | Adeh_4119 | Glycine cleavage H-protein. | Glycine cleavage H-protein. | 0.916 |
| Adeh_2003 | folD | Adeh_2003 | Adeh_1247 | Glycine cleavage H-protein. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.975 |
| Adeh_2003 | gcvH | Adeh_2003 | Adeh_1244 | Glycine cleavage H-protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.921 |
| Adeh_2003 | gcvPA | Adeh_2003 | Adeh_1243 | Glycine cleavage H-protein. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.983 |
| Adeh_2003 | gcvPB | Adeh_2003 | Adeh_1242 | Glycine cleavage H-protein. | Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.992 |
| Adeh_2003 | gcvT | Adeh_2003 | Adeh_1245 | Glycine cleavage H-protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.994 |
| Adeh_2003 | glyA | Adeh_2003 | Adeh_2744 | Glycine cleavage H-protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
