node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Csal_0158 | Csal_1125 | Csal_0158 | Csal_1125 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.917 |
Csal_0158 | bioB | Csal_0158 | Csal_1167 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.573 |
Csal_0158 | bioD | Csal_0158 | Csal_1163 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.572 |
Csal_0158 | bioF | Csal_0158 | Csal_1166 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.478 |
Csal_0158 | birA | Csal_0158 | Csal_0406 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.550 |
Csal_1125 | Csal_0158 | Csal_1125 | Csal_0158 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.917 |
Csal_1125 | bioB | Csal_1125 | Csal_1167 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.671 |
Csal_1125 | bioD | Csal_1125 | Csal_1163 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.670 |
Csal_1125 | bioF | Csal_1125 | Csal_1166 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.402 |
Csal_1125 | birA | Csal_1125 | Csal_0406 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.486 |
Csal_1162 | Csal_1165 | Csal_1162 | Csal_1165 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Carboxylesterase BioH (pimeloyl-CoA synthesis). | 0.785 |
Csal_1162 | bioB | Csal_1162 | Csal_1167 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.981 |
Csal_1162 | bioC | Csal_1162 | Csal_1164 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | pimeloyl-CoA biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.821 |
Csal_1162 | bioD | Csal_1162 | Csal_1163 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.997 |
Csal_1162 | bioF | Csal_1162 | Csal_1166 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.992 |
Csal_1162 | birA | Csal_1162 | Csal_0406 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.486 |
Csal_1165 | Csal_1162 | Csal_1165 | Csal_1162 | Carboxylesterase BioH (pimeloyl-CoA synthesis). | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.785 |
Csal_1165 | bioB | Csal_1165 | Csal_1167 | Carboxylesterase BioH (pimeloyl-CoA synthesis). | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.894 |
Csal_1165 | bioC | Csal_1165 | Csal_1164 | Carboxylesterase BioH (pimeloyl-CoA synthesis). | pimeloyl-CoA biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.956 |
Csal_1165 | bioD | Csal_1165 | Csal_1163 | Carboxylesterase BioH (pimeloyl-CoA synthesis). | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.910 |