node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Jann_1026 | Jann_1978 | Jann_1026 | Jann_1978 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | metFprotein-like protein. | 0.935 |
Jann_1026 | Jann_2079 | Jann_1026 | Jann_2079 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase. | 0.934 |
Jann_1026 | Jann_3620 | Jann_1026 | Jann_3620 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein. | 0.912 |
Jann_1026 | folD | Jann_1026 | Jann_0983 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.951 |
Jann_1026 | glyA | Jann_1026 | Jann_2991 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
Jann_1978 | Jann_1026 | Jann_1978 | Jann_1026 | metFprotein-like protein. | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.935 |
Jann_1978 | Jann_2079 | Jann_1978 | Jann_2079 | metFprotein-like protein. | Serine hydroxymethyltransferase. | 0.930 |
Jann_1978 | Jann_3620 | Jann_1978 | Jann_3620 | metFprotein-like protein. | Glycine cleavage system T protein. | 0.911 |
Jann_1978 | folD | Jann_1978 | Jann_0983 | metFprotein-like protein. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.920 |
Jann_1978 | glyA | Jann_1978 | Jann_2991 | metFprotein-like protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
Jann_2079 | Jann_1026 | Jann_2079 | Jann_1026 | Serine hydroxymethyltransferase. | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.934 |
Jann_2079 | Jann_1978 | Jann_2079 | Jann_1978 | Serine hydroxymethyltransferase. | metFprotein-like protein. | 0.930 |
Jann_2079 | Jann_3620 | Jann_2079 | Jann_3620 | Serine hydroxymethyltransferase. | Glycine cleavage system T protein. | 0.981 |
Jann_2079 | fhs | Jann_2079 | Jann_0981 | Serine hydroxymethyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.949 |
Jann_2079 | fmt | Jann_2079 | Jann_0469 | Serine hydroxymethyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.915 |
Jann_2079 | folD | Jann_2079 | Jann_0983 | Serine hydroxymethyltransferase. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.968 |
Jann_2079 | glyA | Jann_2079 | Jann_2991 | Serine hydroxymethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
Jann_2079 | purH | Jann_2079 | Jann_4042 | Serine hydroxymethyltransferase. | IMP cyclohydrolase. | 0.979 |
Jann_2079 | purN | Jann_2079 | Jann_1837 | Serine hydroxymethyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.955 |
Jann_3386 | folD | Jann_3386 | Jann_0983 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |