node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GOX1095 | GOX1852 | GOX1095 | GOX1852 | Aminomethyltransferase (Glycine cleavage system T protein). | Glutamate synthase [NADPH] large chain. | 0.903 |
GOX1095 | GOX2022 | GOX1095 | GOX2022 | Aminomethyltransferase (Glycine cleavage system T protein). | Aminomethyltransferase; Belongs to the GcvT family. | 0.775 |
GOX1095 | GOX2292 | GOX1095 | GOX2292 | Aminomethyltransferase (Glycine cleavage system T protein). | Dihydrolipoamide dehydrogenase. | 0.931 |
GOX1095 | gcvH | GOX1095 | GOX1096 | Aminomethyltransferase (Glycine cleavage system T protein). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.991 |
GOX1095 | gcvP | GOX1095 | GOX1097 | Aminomethyltransferase (Glycine cleavage system T protein). | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
GOX1095 | glyA | GOX1095 | GOX2310 | Aminomethyltransferase (Glycine cleavage system T protein). | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.990 |
GOX1764 | GOX1852 | GOX1764 | GOX1852 | Glutathione reductase. | Glutamate synthase [NADPH] large chain. | 0.471 |
GOX1764 | GOX2022 | GOX1764 | GOX2022 | Glutathione reductase. | Aminomethyltransferase; Belongs to the GcvT family. | 0.460 |
GOX1764 | GOX2290 | GOX1764 | GOX2290 | Glutathione reductase. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
GOX1764 | gcvH | GOX1764 | GOX1096 | Glutathione reductase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.862 |
GOX1764 | gcvP | GOX1764 | GOX1097 | Glutathione reductase. | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.573 |
GOX1852 | GOX1095 | GOX1852 | GOX1095 | Glutamate synthase [NADPH] large chain. | Aminomethyltransferase (Glycine cleavage system T protein). | 0.903 |
GOX1852 | GOX1764 | GOX1852 | GOX1764 | Glutamate synthase [NADPH] large chain. | Glutathione reductase. | 0.471 |
GOX1852 | GOX2022 | GOX1852 | GOX2022 | Glutamate synthase [NADPH] large chain. | Aminomethyltransferase; Belongs to the GcvT family. | 0.575 |
GOX1852 | GOX2290 | GOX1852 | GOX2290 | Glutamate synthase [NADPH] large chain. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.459 |
GOX1852 | GOX2292 | GOX1852 | GOX2292 | Glutamate synthase [NADPH] large chain. | Dihydrolipoamide dehydrogenase. | 0.889 |
GOX1852 | gcvH | GOX1852 | GOX1096 | Glutamate synthase [NADPH] large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.886 |
GOX1852 | gcvP | GOX1852 | GOX1097 | Glutamate synthase [NADPH] large chain. | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.899 |
GOX1852 | glyA | GOX1852 | GOX2310 | Glutamate synthase [NADPH] large chain. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.463 |
GOX1852 | lipA | GOX1852 | GOX2293 | Glutamate synthase [NADPH] large chain. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.408 |