node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GOX0744 | GOX1101 | GOX0744 | GOX1101 | Nitrogen regulatory protein P-II, GlnK. | Glutamine synthetase. | 0.667 |
GOX0744 | GOX1852 | GOX0744 | GOX1852 | Nitrogen regulatory protein P-II, GlnK. | Glutamate synthase [NADPH] large chain. | 0.601 |
GOX0744 | glnD | GOX0744 | GOX1872 | Nitrogen regulatory protein P-II, GlnK. | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.910 |
GOX0744 | guaA | GOX0744 | GOX1950 | Nitrogen regulatory protein P-II, GlnK. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.434 |
GOX1101 | GOX0744 | GOX1101 | GOX0744 | Glutamine synthetase. | Nitrogen regulatory protein P-II, GlnK. | 0.667 |
GOX1101 | GOX1852 | GOX1101 | GOX1852 | Glutamine synthetase. | Glutamate synthase [NADPH] large chain. | 0.982 |
GOX1101 | glnD | GOX1101 | GOX1872 | Glutamine synthetase. | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.655 |
GOX1101 | guaA | GOX1101 | GOX1950 | Glutamine synthetase. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.584 |
GOX1101 | ribB | GOX1101 | GOX0980 | Glutamine synthetase. | 3,4-Dihydroy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.422 |
GOX1852 | GOX0744 | GOX1852 | GOX0744 | Glutamate synthase [NADPH] large chain. | Nitrogen regulatory protein P-II, GlnK. | 0.601 |
GOX1852 | GOX1101 | GOX1852 | GOX1101 | Glutamate synthase [NADPH] large chain. | Glutamine synthetase. | 0.982 |
GOX1852 | glnD | GOX1852 | GOX1872 | Glutamate synthase [NADPH] large chain. | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.598 |
GOX1852 | guaA | GOX1852 | GOX1950 | Glutamate synthase [NADPH] large chain. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.648 |
GOX1852 | guaB | GOX1852 | GOX2265 | Glutamate synthase [NADPH] large chain. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.614 |
GOX1852 | pstB | GOX1852 | GOX0704 | Glutamate synthase [NADPH] large chain. | Phosphate transport ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.485 |
GOX1873 | glnD | GOX1873 | GOX1872 | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.817 |
GOX1873 | murJ | GOX1873 | GOX1874 | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. | Virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.687 |
GOX1873 | ribB | GOX1873 | GOX0980 | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. | 3,4-Dihydroy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.416 |
bamA | glnD | GOX1818 | GOX1872 | Outer membrane protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.450 |
glnD | GOX0744 | GOX1872 | GOX0744 | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Nitrogen regulatory protein P-II, GlnK. | 0.910 |