STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATRIPLOW QUALITY PROTEIN: ATR-interacting protein. (548 aa)    
Predicted Functional Partners:
ATR
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
    
 0.996
FANCM
LOW QUALITY PROTEIN: Fanconi anemia group M protein.
     
 0.969
FANCI
Fanconi anemia group I protein.
     
 0.961
FANCG
Fanconi anemia group G protein isoform X1.
   
 
 0.955
ENSUMAP00000000566
annotation not available
 
     0.916
TOPBP1
DNA topoisomerase 2-binding protein 1 isoform X1.
    
 0.884
WRN
LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.
     
 0.839
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.819
RAD17
Cell cycle checkpoint protein RAD17 isoform X1.
    
 0.817
CLSPN
LOW QUALITY PROTEIN: claspin.
     
 0.809
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.