STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CASP6Caspase-6; Belongs to the peptidase C14A family. (140 aa)    
Predicted Functional Partners:
LMNB1
lamin-B1; Belongs to the intermediate filament family.
   
 0.988
CASP8
Caspase-8 isoform X1; Belongs to the peptidase C14A family.
   
0.963
CASP9
Caspase-9 isoform X1; Belongs to the peptidase C14A family.
    
0.960
ACTG1
LOW QUALITY PROTEIN: actin, cytoplasmic 2.
    
 0.920
LMNA
Lamin A/C.
   
 0.910
SATB1
DNA-binding protein SATB.
    
 0.875
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.859
CYCS
Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
   
 0.838
VIM
Vimentin; Belongs to the intermediate filament family.
   
 0.794
CASP10
Caspase-10 isoform X1; Belongs to the peptidase C14A family.
   
0.686
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.