STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103657111Lutropin subunit beta. (140 aa)    
Predicted Functional Partners:
CGA
Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.
   
 0.992
LHCGR
Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
   
 0.960
FSHR
Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
   
 0.928
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
   
 0.923
ADCYAP1R1
Pituitary adenylate cyclase-activating polypeptide type I receptor; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.874
ADRB2
Beta-2 adrenergic receptor.
     
 0.866
HTR4
LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.
     
 0.866
GLP1R
Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.
   
 
  0.865
VIPR2
Vasoactive intestinal polypeptide receptor 2; Belongs to the G-protein coupled receptor 2 family.
   
 
  0.865
GIPR
Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.
   
 
  0.865
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.