STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMFRE3 ubiquitin-protein ligase AMFR. (597 aa)    
Predicted Functional Partners:
DERL1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
 0.996
VCP
Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.
    
 0.958
UBE2G2
Ubiquitin-conjugating enzyme E2 G2 isoform X2; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.955
DERL2
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
   
 0.949
NGLY1
peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase.
   
 0.948
UBXN1
UBX domain-containing protein 1 isoform X1.
    
 0.947
OS9
Protein OS-9.
   
 0.930
SEL1L
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 0.920
RPS27A
ubiquitin-40S ribosomal protein S27a.
    
 0.889
RAD23B
LOW QUALITY PROTEIN: UV excision repair protein RAD23 homolog B.
    
 0.882
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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