IDE protein (Ursus maritimus) - STRING interaction network

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gene neighborhood

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Score

IDE

Insulin-degrading enzyme; Belongs to the peptidase M16 family. (1016 aa)

Predicted Functional Partners:

INS-IGF2

0.987

APP

0.926

BACE1

0.905

IAPP

0.897

USP4

0.888

RPS27A

0.882

MME

0.881

MMEL1

0.841

IFITM10

0.809

NPPA

0.782

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	BACE1	ENSUMAP00000020202	ENSUMAP00000002915	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Beta-secretase 1 isoform X2; Belongs to the peptidase A1 family.	0.943
APP	IAPP	ENSUMAP00000020202	ENSUMAP00000004752	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Islet amyloid polypeptide.	0.735
APP	IDE	ENSUMAP00000020202	ENSUMAP00000002997	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	0.926
APP	IFITM10	ENSUMAP00000020202	ENSUMAP00000007925	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Interferon-induced transmembrane protein 10.	0.543
APP	INS-IGF2	ENSUMAP00000020202	ENSUMAP00000008147	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.542
APP	MME	ENSUMAP00000020202	ENSUMAP00000016153	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Neprilysin isoform X2.	0.648
APP	MMEL1	ENSUMAP00000020202	ENSUMAP00000014300	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Membrane metallo-endopeptidase-like 1.	0.648
BACE1	APP	ENSUMAP00000002915	ENSUMAP00000020202	Beta-secretase 1 isoform X2; Belongs to the peptidase A1 family.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.943
BACE1	IDE	ENSUMAP00000002915	ENSUMAP00000002997	Beta-secretase 1 isoform X2; Belongs to the peptidase A1 family.	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	0.905
BACE1	INS-IGF2	ENSUMAP00000002915	ENSUMAP00000008147	Beta-secretase 1 isoform X2; Belongs to the peptidase A1 family.	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.490
BACE1	MME	ENSUMAP00000002915	ENSUMAP00000016153	Beta-secretase 1 isoform X2; Belongs to the peptidase A1 family.	Neprilysin isoform X2.	0.749
BACE1	MMEL1	ENSUMAP00000002915	ENSUMAP00000014300	Beta-secretase 1 isoform X2; Belongs to the peptidase A1 family.	Membrane metallo-endopeptidase-like 1.	0.839
IAPP	APP	ENSUMAP00000004752	ENSUMAP00000020202	Islet amyloid polypeptide.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.735
IAPP	IDE	ENSUMAP00000004752	ENSUMAP00000002997	Islet amyloid polypeptide.	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	0.897
IAPP	INS-IGF2	ENSUMAP00000004752	ENSUMAP00000008147	Islet amyloid polypeptide.	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.780
IDE	APP	ENSUMAP00000002997	ENSUMAP00000020202	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.926
IDE	BACE1	ENSUMAP00000002997	ENSUMAP00000002915	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	Beta-secretase 1 isoform X2; Belongs to the peptidase A1 family.	0.905
IDE	IAPP	ENSUMAP00000002997	ENSUMAP00000004752	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	Islet amyloid polypeptide.	0.897
IDE	IFITM10	ENSUMAP00000002997	ENSUMAP00000007925	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	Interferon-induced transmembrane protein 10.	0.809
IDE	INS-IGF2	ENSUMAP00000002997	ENSUMAP00000008147	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.987