STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALAS25-aminolevulinate synthase. (590 aa)    
Predicted Functional Partners:
ALAS1
5-aminolevulinate synthase.
  
  
 
0.799
ALAD
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
    
 0.756
SORD
Sorbitol dehydrogenase.
 
 
 0.753
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
  
  
 0.671
SLC25A38
Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
      
 0.636
GATA1
LOW QUALITY PROTEIN: erythroid transcription factor.
   
 
 0.634
EPB42
Erythrocyte membrane protein band 4.2.
   
 
 0.628
SLC4A1
Anion exchange protein.
   
  
 0.627
AHSP
Alpha-hemoglobin-stabilizing protein.
   
  
 0.617
ADHFE1
Hydroxyacid-oxoacid transhydrogenase, mitochondrial.
    
 0.588
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.