RASGRF2 protein (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RASGRF2

Ras-specific guanine nucleotide-releasing factor 2. (1237 aa)

Predicted Functional Partners:

KRAS

0.939

HRAS

0.939

NRAS

0.939

RRAS

0.935

RRAS2

0.933

LOC103663361

0.922

PRKACB

0.919

PRKACA

0.919

CALML5

0.918

GNG4

0.913

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML5	HRAS	ENSUMAP00000016509	ENSUMAP00000007088	Calmodulin-like protein 5.	GTPase HRas isoform X1.	0.935
CALML5	KRAS	ENSUMAP00000016509	ENSUMAP00000004007	Calmodulin-like protein 5.	GTPase KRas isoform X3.	0.937
CALML5	NRAS	ENSUMAP00000016509	ENSUMAP00000015942	Calmodulin-like protein 5.	NRAS proto-oncogene, GTPase.	0.935
CALML5	PRKACA	ENSUMAP00000016509	ENSUMAP00000005724	Calmodulin-like protein 5.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.975
CALML5	PRKACB	ENSUMAP00000016509	ENSUMAP00000003099	Calmodulin-like protein 5.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.976
CALML5	RASGRF2	ENSUMAP00000016509	ENSUMAP00000003939	Calmodulin-like protein 5.	Ras-specific guanine nucleotide-releasing factor 2.	0.918
GNG4	HRAS	ENSUMAP00000009513	ENSUMAP00000007088	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	GTPase HRas isoform X1.	0.672
GNG4	KRAS	ENSUMAP00000009513	ENSUMAP00000004007	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	GTPase KRas isoform X3.	0.672
GNG4	LOC103663361	ENSUMAP00000009513	ENSUMAP00000002061	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.505
GNG4	NRAS	ENSUMAP00000009513	ENSUMAP00000015942	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NRAS proto-oncogene, GTPase.	0.672
GNG4	PRKACA	ENSUMAP00000009513	ENSUMAP00000005724	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.650
GNG4	PRKACB	ENSUMAP00000009513	ENSUMAP00000003099	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.650
GNG4	RASGRF2	ENSUMAP00000009513	ENSUMAP00000003939	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Ras-specific guanine nucleotide-releasing factor 2.	0.913
GNG4	RRAS	ENSUMAP00000009513	ENSUMAP00000002904	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Ras-related protein R-Ras.	0.677
GNG4	RRAS2	ENSUMAP00000009513	ENSUMAP00000023336	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	LOW QUALITY PROTEIN: ras-related protein R-Ras2.	0.676
HRAS	CALML5	ENSUMAP00000007088	ENSUMAP00000016509	GTPase HRas isoform X1.	Calmodulin-like protein 5.	0.935
HRAS	GNG4	ENSUMAP00000007088	ENSUMAP00000009513	GTPase HRas isoform X1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.672
HRAS	KRAS	ENSUMAP00000007088	ENSUMAP00000004007	GTPase HRas isoform X1.	GTPase KRas isoform X3.	0.936
HRAS	LOC103663361	ENSUMAP00000007088	ENSUMAP00000002061	GTPase HRas isoform X1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.672
HRAS	NRAS	ENSUMAP00000007088	ENSUMAP00000015942	GTPase HRas isoform X1.	NRAS proto-oncogene, GTPase.	0.901