node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC45 | CDC6 | ENSUMAP00000009200 | ENSUMAP00000024485 | Cell division control protein 45 homolog. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.958 |
CDC45 | CDT1 | ENSUMAP00000009200 | ENSUMAP00000011034 | Cell division control protein 45 homolog. | DNA replication factor Cdt1. | 0.974 |
CDC45 | MCM10 | ENSUMAP00000009200 | ENSUMAP00000018135 | Cell division control protein 45 homolog. | Protein MCM10 homolog isoform X1. | 0.998 |
CDC45 | MCM3 | ENSUMAP00000009200 | ENSUMAP00000005511 | Cell division control protein 45 homolog. | DNA helicase; Belongs to the MCM family. | 0.997 |
CDC45 | MCM4 | ENSUMAP00000009200 | ENSUMAP00000008557 | Cell division control protein 45 homolog. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC45 | MCM5 | ENSUMAP00000009200 | ENSUMAP00000023262 | Cell division control protein 45 homolog. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDC45 | MCM7 | ENSUMAP00000009200 | ENSUMAP00000014080 | Cell division control protein 45 homolog. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.996 |
CDC45 | MCM9 | ENSUMAP00000009200 | ENSUMAP00000003383 | Cell division control protein 45 homolog. | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. | 0.966 |
CDC45 | ORC1 | ENSUMAP00000009200 | ENSUMAP00000031377 | Cell division control protein 45 homolog. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.968 |
CDC45 | TM4SF19 | ENSUMAP00000009200 | ENSUMAP00000003946 | Cell division control protein 45 homolog. | Transmembrane 4 L6 family member 19. | 0.951 |
CDC6 | CDC45 | ENSUMAP00000024485 | ENSUMAP00000009200 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cell division control protein 45 homolog. | 0.958 |
CDC6 | CDT1 | ENSUMAP00000024485 | ENSUMAP00000011034 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication factor Cdt1. | 0.999 |
CDC6 | MCM10 | ENSUMAP00000024485 | ENSUMAP00000018135 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Protein MCM10 homolog isoform X1. | 0.981 |
CDC6 | MCM3 | ENSUMAP00000024485 | ENSUMAP00000005511 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDC6 | MCM4 | ENSUMAP00000024485 | ENSUMAP00000008557 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC6 | MCM5 | ENSUMAP00000024485 | ENSUMAP00000023262 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDC6 | MCM7 | ENSUMAP00000024485 | ENSUMAP00000014080 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.998 |
CDC6 | MCM9 | ENSUMAP00000024485 | ENSUMAP00000003383 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. | 0.970 |
CDC6 | ORC1 | ENSUMAP00000024485 | ENSUMAP00000031377 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
CDC6 | TM4SF19 | ENSUMAP00000024485 | ENSUMAP00000003946 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Transmembrane 4 L6 family member 19. | 0.956 |